Cytotoxic, antiproliferative and apoptotic effects of new benzimidazole derivatives on A549 lung carcinoma and C6 glioma cell lines

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dc.contributor.authorYurttaş, Leyla
dc.contributor.authorDemirayak, Şeref
dc.contributor.authorÇiftçi, Gülşen Akalın
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:45Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:45Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.description.abstractBenzimidazole ring is a versatile structure which has been extensively utilized in medicinal chemistry. Since we are working on 1,2-disubstutited benzimidazoles, we have reported new antitumor active derivatives. As a continuation to our previous work, we have synthesized a new series of 1-(2-aryl-2-oxoethyl)-2-[(N,N- dimethylamino/pyrrolidinyl/piperidinyl)thiocarbamoyl] benzimidazole derivatives. Anticancer activity of the compounds was evaluated using MTT assay, BrdU assay and flow cytometric analysis on A549 human lung carcinoma and C6 rat glioma cell lines. Compounds bearing dimethylamino moiety exhibited higher antitumor activity.
dc.identifier.citationYurttaş L., Demirayak Ş. ve Çiftçi, G. A. (2015). Cytotoxic, antiproliferative and apoptotic effects of new benzimidazole derivatives on A549 lung carcinoma and C6 glioma cell lines. Anti-Cancer Agents in Medicinal Chemistry, 15(9), 1174-1184. https://dx.doi.org/10.2174/1871520615666150703122625
dc.identifier.doi10.2174/1871520615666150703122625
dc.identifier.endpage1184
dc.identifier.issn1871-5206
dc.identifier.issue9
dc.identifier.scopusqualityQ2
dc.identifier.startpage1174
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1246
dc.identifier.urihttps://dx.doi.org/10.2174/1871520615666150703122625
dc.identifier.volume15
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publishers
dc.relation.ispartofAnti-Cancer Agents in Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntiproliferative
dc.subjectApoptosis
dc.subjectBenzimidazole
dc.subjectCytotoxicity
dc.titleCytotoxic, antiproliferative and apoptotic effects of new benzimidazole derivatives on A549 lung carcinoma and C6 glioma cell lines
dc.typeArticle

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