A comparative investigation on the in vitro anti-inflammatory, antioxidant and antimicrobial potentials of subextracts from the aerial parts of Daphne oleoides Schreb. subsp oleoides

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dc.authorid0000-0002-7921-8621
dc.authorid0000-0002-4702-4486
dc.contributor.authorAtay Balkan, İrem
dc.contributor.authorTaşkın, Turgut
dc.contributor.authorDoğan, Hacer Tuğba
dc.contributor.authorDeniz, İnci
dc.contributor.authorAkaydın, Galip
dc.contributor.authorYeşilada, Erdem
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:24Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:24Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı
dc.descriptionWOS: 000390621600079
dc.description.abstractDaphne oleoides Schreb. subsp. oleoides is an evergreen shrub which is known for its folkloric usage against various ailments such as arthritic and infectious diseases. The aim of the present study was to comparatively investigate the in vitro anti-inflammatory (nitric oxide inhibitory effects), antioxidant (DPPH center dot,ABTS(center dot+) and FRAP tests) and antimicrobial activities of the extract/subextracts from the aerial parts of D. oleoides Schreb. subsp. oleoides (Thymelaeaceae). The powdered aerial parts were first extracted with methanol and then partitioned into five subextracts (n-hexane, dichloromethane (CH2Cl2), ethyl acetate (EtOAC), n-butanol and remaining water) by succesive solvent extractions. The chemical compositions of the extracts were compared with regard to their total phenolic, total flavonoid contents and fatty acid compositions. The CH2Cl2 and n-hexane extracts exerted the highest inhibitory effect on NO production (61.67 +/- 13.97% inhibition at 50 mu g/ml and 67.91 +/- 11.17% inhibition at 100 mu g/ml, respectively) of LPS-induced Raw 264.7 cells. The EtOAC subextract showed the highest antioxidant effect evaluated by DPPH center dot (IC50: 0.35 +/- 0.12 mg/ml) and FRAP (4.54 +/- 10.01 mM FeSO4/mg extract) tests. The CH2Cl2 subextract was shown to contain the highest levels of flavonoids (0.837 +/- 10.035 mg QUE/mg extract) and was also found to be rich in phenolics (1.063 +/- 10.011 mg GAE/mg extract). Fatty acid analysis of the n-hexane extract revealed hexadecahoic acid and 9,15-octodecadienoic acids to be the major components. The n-hexane and CH2Cl2 subextracts exerted the'highest antimicrobial potential.
dc.identifier.citationAtay Balkan, İ., Taşkın, T., Doğan, H. T., Deniz, İ., Akaydın, G. ve Yeşilada, E. (2017). A comparative investigation on the in vitro anti-inflammatory, antioxidant and antimicrobial potentials of subextracts from the aerial parts of Daphne oleoides Schreb. subsp oleoides. Industrial Crops and Products, 95, 695-703. https://dx.doi.org/10.1016/j.indcrop.2016.11.038
dc.identifier.doi10.1016/j.indcrop.2016.11.038
dc.identifier.endpage703
dc.identifier.issn0926-6690
dc.identifier.issn1872-633X
dc.identifier.scopusqualityQ1
dc.identifier.startpage695
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2016.11.038
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2696
dc.identifier.volume95
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofIndustrial Crops and Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectDaphne Oleoides Subsp Oleoides
dc.subjectAnti-Inflammatory
dc.subjectAntioxidant
dc.subjectAntimicrobial
dc.subjectPhenolics
dc.subjectFatty Acids
dc.titleA comparative investigation on the in vitro anti-inflammatory, antioxidant and antimicrobial potentials of subextracts from the aerial parts of Daphne oleoides Schreb. subsp oleoides
dc.typeArticle

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