Immunomodulator effect of topical zinc oxide application in tuberculin skin test

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dc.authorid0000-0002-8968-4079
dc.contributor.authorNuhoğlu, Çağatay
dc.contributor.authorHepkaya, Evrim
dc.contributor.authorÖnal, Zehra Esra
dc.contributor.authorAkıcı, Narin
dc.contributor.authorGürbüz, Tamay
dc.contributor.authorAtasayan, Vildan
dc.contributor.authorCeran, Ömer
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:09Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:09Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000433094100008
dc.descriptionPubMed ID: 29607430
dc.description.abstractOBJECTIVE: We aimed to evaluate the sensitivity of tuberculin skintest (purified protein derivative-PPD) by topical zinc application on test site to improve diagnostic reliability. METHODS: We performed this study in 100 children aged 6-14 years, and plasma zinc levels were analyzed after 10-12 hours fasting. After PPD, we applied 40% zinc oxide cream on one forearm and placebo on the other forearm. PPD indurations were measured 72 hours later. RESULTS: In this study, 26% of the children showed increases in PPD induration following local zinc applications. There was no correlation between indurations size and serum zinc levels. CONCLUSION: We concluded that topical zinc cream application can enhance sensitivity of tuberculin reactivityin the diagnosis of tuberculosis.
dc.identifier.citationNuhoğlu, Ç., Hepkaya, E., Önal, Z. E., Akıcı, N., Gürbüz, T., Atasayan, V. ve Ceran, Ö. (2018). Immunomodulator effect of topical zinc oxide application in tuberculin skin test. Northern Clinics of Istanbul, 5(1), 37-40. https://dx.doi.org/10.14744/nci.2017.88896
dc.identifier.doi10.14744/nci.2017.88896
dc.identifier.endpage40
dc.identifier.issn2148-4902
dc.identifier.issue1
dc.identifier.startpage37
dc.identifier.urihttps://dx.doi.org/10.14744/nci.2017.88896
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3567
dc.identifier.volume5
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKare Publisher
dc.relation.ispartofNorthern Clinics of Istanbulen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPurified Protein Derivative
dc.subjectTuberculin Skin Test
dc.subjectZinc
dc.titleImmunomodulator effect of topical zinc oxide application in tuberculin skin test
dc.typeArticle

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