Axolotl cells and tissues enhances cutaneous wound healing in mice

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dc.authorid0000-0002-7059-1884
dc.authorid0000-0001-7933-4262
dc.authorid0000-0003-0352-1947
dc.contributor.authorDemircan, Turan
dc.contributor.authorKeskin, İlknur
dc.contributor.authorGünal, Yalçın
dc.contributor.authorİlhan, Ayşe Elif
dc.contributor.authorKolbaşı, Bircan
dc.contributor.authorÖztürk, Gürkan
dc.date.accessioned08.07.201910:49:13
dc.date.accessioned2019-07-08T20:18:44Z
dc.date.available08.07.201910:49:13
dc.date.available2019-07-08T20:18:44Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.description.abstractAdult mammalian skin wound repair is defective due to loss of the regulation in balancing the complete epithelial regeneration and excessive connective tissue production, and this repair process commonly results in scar tissue formation. However, unlike mammals, adult salamanders repair the wounds by regeneration compared to scarring. To elucidate the healing capability of a salamander, Axolotl, in a different species, here we addressed this question by treating the wounds in mice with Axolotl cells or tissues. Excisional lesions were created on each mouse, and animals in different groups treated by; a-) Axolotl blastema tissue, b-) Axolotl tail tissue, c-) Axolotl blastema cells, d-) Axolotl tail cells, e-) Serum physiologic, e-) Madecassol; respectively. 10 days after the treatments, wound healing success was compared by considering the wound closure rate, histopathological analysis, vascularization and gene expression profiling of cytokines. The results reveal that Axolotl cells or tissues delivered animals demonstrate an improved wound repair capacity. A better reepithelization, granule tissue formation, vascularization and even presence of hair follicles are observed in animals treated with Axolotl samples. Gene expression profiling data discloses the lower levels of pro-inflammatory cytokines in these animals which may indicate the immune-modulating role of Axolotl samples in wound healing.
dc.identifier.citationDemircan, T., Keskin, İ., Günal, Y., İlhan, A. E., Kolbaşı, B. ve Öztürk, G. (2016). Axolotl cells and tissues enhances cutaneous wound healing in mice. Journal of Experimental and Clinical Medicine, 33(4), 229-237. https://dx.doi.org/10.5835/jecm.omu.33.04.010
dc.identifier.endpage237
dc.identifier.issn1309-4483
dc.identifier.issue4
dc.identifier.scopusqualityQ4
dc.identifier.startpage229
dc.identifier.urihttps://hdl.handle.net/20.500.12511/454
dc.identifier.urihttps://dx.doi.org/10.5835/jecm.omu.33.04.010
dc.identifier.volume33
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofJournal of Experimental and Clinical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectAxolotl
dc.subjectCutaneous Wound Healing
dc.subjectImmune-Modulation
dc.subjectRegeneration
dc.titleAxolotl cells and tissues enhances cutaneous wound healing in mice
dc.typeArticle

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