Development and validation of an HPLC method for voriconazole active substance in bulk and its pharmaceutical formulation

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dc.authorid0000-0002-3210-3747
dc.authorid0000-0003-2010-4918
dc.authorid0000-0001-8018-6500
dc.contributor.authorÜstündağ Okur, Neslihan
dc.contributor.authorÇağlar, Emre Sefik
dc.contributor.authorYozgatlı, Vildan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:41Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:41Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.descriptionWOS: 000379969900004
dc.description.abstractThe aim of the present study was to develop and validate a High-Performance Liquid Chromatography (HPLC) method for the determination of voriconazole in drug substances and in situ gel. A mixture of acetonitrile and ultrapure water (50: 50) (v/v) was used as mobile phase. The column was a C18 column (150x4.6mm with 5 mu m particles). The eluent was monitored with UV detection at 256 nm and flow rate was set to 1 mL/min. The method was validated partially with respect to system suitability, linearity, limits of detection (LOD) and quantitation (LOQ), precision, accuracy, specificity, selectivity and stability. Obtained results showed that the analytical method had good linearity, accuracy, precision, selectivity and stability. Analytical method development results indicated that the LOD was 0.022 mu g/mL; LOQ was 0.065 mu g/mL and assay exhibited a linear range of 1-30 mu g/mL.
dc.identifier.citationÜstündağ Okur, N., Çağlar, Emre Ş. ve Yozgatlı, V. (2016). Development and validation of an HPLC method for voriconazole active substance in bulk and its pharmaceutical formulation. Marmara Pharmaceutical Journal, 20(2), 79-85. https://dx.doi.org/10.12991/mpj.20162076793
dc.identifier.doi10.12991/mpj.20162076793
dc.identifier.endpage85
dc.identifier.issn1309-0801
dc.identifier.issue2
dc.identifier.scopusqualityQ3
dc.identifier.startpage79
dc.identifier.urihttps://dx.doi.org/10.12991/mpj.20162076793
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3403
dc.identifier.volume20
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMarmara University
dc.relation.ispartofMarmara Pharmaceutical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectVoriconazole
dc.subjectHPLC
dc.subjectMethod
dc.subjectValidation
dc.titleDevelopment and validation of an HPLC method for voriconazole active substance in bulk and its pharmaceutical formulation
dc.typeArticle

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