Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish

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dc.authorid0000-0003-0804-1475
dc.contributor.authorYurtsever, İlknur
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorÜnal, İsmail
dc.contributor.authorAteş, Perihan Seda
dc.contributor.authorEmekli Alturfan, Ebru
dc.date.accessioned2023-01-11T11:09:36Z
dc.date.available2023-01-11T11:09:36Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Klinik Eczacılık Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractAmong the mechanisms underlying Parkinson’s disease, many pathogenic mechanisms are suggested to be effective such as oxidative stress, mitochondrial dysfunction, disruption of the ubiquitin-proteasome system, and neuroinflammation. Calcium is very important for neuronal and glial cells, neurodegenerative disease mechanisms are closely related to disturbed calcium homeostasis. Recent studies strongly support the role of inflammation in nigrostriatal degeneration in PD. In recent years, Rifampicin, a macrocyclic antibiotic has been shown to have a protective effect on neurons. This study aims to evaluate the effects of rifampicin in the experimental PD model induced by rotenone in zebrafish focusing on the relationship between calcium-dependent mitochondrial dysfunction and inflammation. Adult zebrafish were exposed to rotenone and rifampicin for 3 weeks. Locomotor activity was determined as the total distance that the zebrafish traveled for 5 min. Neuroinflammation and PD-related gene expressions were determined by RT-PCR. Mitochondrial calcium levels were determined using inductively coupled plasma-optical emission spectrometry (ICP-OES). Gamma synuclein, Park 7, Sigma-1 receptor expressions were determined by Western Blot. Our results show that rifampicin may be effective in reducing neuroinflammation, which may be an effective strategy to reduce mitochondrial dysfunction due to impaired calcium homeostasis in PD.
dc.description.sponsorshipMarmara Universityen_US
dc.identifier.citationYurtsever, İ., Üstündağ, Ü. V., Ünal, İ., Ateş, P. S. ve Emekli Alturfan, E. (2022). Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish. Drug and Chemical Toxicology, 45(4), 1544-1551. https://dx.doi.org/10.1080/01480545.2020.1846549
dc.identifier.doi10.1080/01480545.2020.1846549
dc.identifier.endpage1551
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue4
dc.identifier.pmid33187454
dc.identifier.scopus2-s2.0-85096124015
dc.identifier.scopusqualityQ3
dc.identifier.startpage1544
dc.identifier.urihttps://dx.doi.org/10.1080/01480545.2020.1846549
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10285
dc.identifier.volume45
dc.identifier.wos000589109300001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYurtsever, İlknur
dc.institutionauthorÜstündağ, Ünsal Veli
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectRifampicin
dc.subjectParkinson’s Disease
dc.subjectNeuroinflammation
dc.subjectCalcium
dc.subjectZebrafish
dc.titleRifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish
dc.typeArticle

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