European association of urology guidelines panel on male sexual and reproductive health: A clinical consultation guide on the indications for performing sperm DNA fragmentation testing in men with infertility and testicular sperm extraction in nonazoospermic men

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dc.authorid0000-0002-2530-7012
dc.contributor.authorTharakan, Tharu
dc.contributor.authorBettocchi, Carlo
dc.contributor.authorCarvalho, Joana
dc.contributor.authorCorona, Giovanni
dc.contributor.authorJones, Thomas Hugh
dc.contributor.authorKadıoğlu, Ateş
dc.contributor.authorMartinez Salamanca, Juan Ignacio
dc.contributor.authorŞerefoğlu, Ege Can
dc.contributor.authorVerze, Paolo
dc.contributor.authorSalonia, Andrea
dc.contributor.authorMinhas, Suks
dc.date.accessioned2022-03-25T08:02:40Z
dc.date.available2022-03-25T08:02:40Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractAccumulating evidence has highlighted the contribution of oxidative stress and sperm DNA fragmentation (SDF) in the pathophysiology of male infertility. SDF has emerged as a novel biomarker of risk stratification for patients undergoing assisted reproductive technologies. Studies have also supported the use of testicular over ejaculated sperm at the time of intracytoplasmic sperm injection, as testicular sperm may have lower SDF than ejaculated samples. The European Association of Urology Working Panel on Male Sexual and Reproductive Health provides an evidence-based consultation guide on the indications for SDF testing in male infertility and also for testicular sperm extraction (TESE) in nonazoospermic men. We present the limitations and advantages of SDF testing and a framework to ensure that it is appropriately utilised in clinical practice. Furthermore, we critically appraise the current literature advocating the use of TESE in nonazoospermic men. Patient summary: This article reviews the evidence supporting the use of sperm DNA fragmentation testing in the assessment of male infertility and testicular sperm extrac-tion in nonazoospermic men.
dc.identifier.citationTharakan, T., Bettocchi, C., Carvalho, J., Corona, G., Jones, T. H., Kadıoğlu, A. ... Minhas, S. (2022). European association of urology guidelines panel on male sexual and reproductive health: A clinical consultation guide on the indications for performing sperm DNA fragmentation testing in men with infertility and testicular sperm extraction in nonazoospermic men. European Urology Focus, 8(1), 339-350. https://doi.org/10.1016/j.euf.2020.12.017
dc.identifier.doi10.1016/j.euf.2020.12.017
dc.identifier.endpage350
dc.identifier.issn2405-4569
dc.identifier.issue1
dc.identifier.pmid33422457
dc.identifier.scopus2-s2.0-85099017314
dc.identifier.scopusqualityQ1
dc.identifier.startpage339
dc.identifier.urihttps://doi.org/10.1016/j.euf.2020.12.017
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9165
dc.identifier.volume8
dc.identifier.wos000760997600045en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞerefoğlu, Ege Can
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofEuropean Urology Focusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAssisted Reproductive Technologies
dc.subjectMale Infertility
dc.subjectSperm DNA Fragmentation
dc.subjectTesticular Sperm Extraction
dc.titleEuropean association of urology guidelines panel on male sexual and reproductive health: A clinical consultation guide on the indications for performing sperm DNA fragmentation testing in men with infertility and testicular sperm extraction in nonazoospermic men
dc.typeArticle

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