Quercetin/polyethyleneimine modified gold nanoconjugates inhibit apoptosis and ros production induced by hydrogen peroxide in drg sensory neurons

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dc.authorid0000-0002-4495-7395
dc.authorid0000-0003-3671-6257
dc.authorid0000-0002-4121-588X
dc.contributor.authorÖzçiçek, İlyas
dc.contributor.authorBaydaş, Gülsena
dc.contributor.authorErim, Ümit Can
dc.contributor.authorÜstündağ, Ünsal Veli
dc.date.accessioned2024-11-04T11:05:09Z
dc.date.available2024-11-04T11:05:09Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractThe basis of most neurological syndromes is the accumulation of free radical molecules. Quercetin is a polyphenolic bioflavonoid molecule and it has a very strong antioxidant effect by maintaining oxidative balance. There are many difficulties in the clinical use of quercetin due to its hydrophobic structure, low solubility, instability, poor oral bioavailability, and limited tissue-barrier penetration. Its synergistic use in complex with gold nanoparticles (AuNPs) could overcome these problems. AuNPs have recently emerged as an attractive candidate for delivery applications of various biomolecules and drugs. The aim of this study was to synthesize two different sized gold nanoparticles (AuNP20 and AuNP50) modified with polyethyleneimine (PEI) and quercetin, evaluate their potential neuroprotective effects on the in vitro oxidative stress model using DRG primary sensory neurons. It was shown that the antioxidant and anti-apoptotic ability of the bioflavonoid was preserved after exposure to the designed quercetin modified AuNPs. The PEI surface coating increased the stability and biocompatibility of the AuNPs in both sizes. It also potentially enables additional surface functionalization. This study indicates that designed nanoparticles (AuNP-Q-PEI) with different sizes could be a useful potential platform for the treatment of neurodegenerative syndromes or cancer diseases.
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu (TÜBİTAK)en_US
dc.identifier.citationÖzçiçek, İ., Baydaş, G., Erim, Ü. C. ve Üstündağ, Ü. V. (2024). Quercetin/polyethyleneimine modified gold nanoconjugates inhibit apoptosis and ros production induced by hydrogen peroxide in drg sensory neurons. Journal of Pharmaceutical Sciences, 113(10), 3088-3099. http://dx.doi.org/10.1016/j.xphs.2024.08.008
dc.identifier.doi10.1016/j.xphs.2024.08.008
dc.identifier.endpage3099
dc.identifier.issn0022-3549
dc.identifier.issn1520-6017
dc.identifier.issue10
dc.identifier.pmid39151794
dc.identifier.scopus2-s2.0-85202056828
dc.identifier.scopusqualityQ2
dc.identifier.startpage3088
dc.identifier.urihttp://dx.doi.org/10.1016/j.xphs.2024.08.008
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12847
dc.identifier.volume113
dc.identifier.wos001330988400001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzçiçek, İlyas
dc.institutionauthorBaydaş, Gülsena
dc.institutionauthorErim, Ümit Can
dc.language.isoen
dc.relation.ispartofJournal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/217S135
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/119S141
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDRG Sensory Neuron
dc.subjectGold Nanoparticle
dc.subjectNanotoxicity
dc.subjectOxidative Stress
dc.subjectQuercetin
dc.titleQuercetin/polyethyleneimine modified gold nanoconjugates inhibit apoptosis and ros production induced by hydrogen peroxide in drg sensory neurons
dc.typeArticle

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