Synthesis and anticancer activity of some 1,2,3-trisubstituted pyrazinobenzimidazole derivatives

Basit Öğe Kaydı
dc.contributor.authorDemirayak, Şeref
dc.contributor.authorYurttas, Leyla
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:05Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:05Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.descriptionWOS: 000345518000007
dc.descriptionPubMed ID: 24456294
dc.description.abstractThe synthesis of some new pyrazino[1,2-a]benzimidazole derivatives and investigation of their anticancer activities were aimed in this work. Thus, 2-acetylbenzimidazole was reacted with appropriate alpha-bromoacetophenones and potassium carbonate in acetone to give 2-(2-acetyl-1H-benzimidazol-1-yl)-1-phenylethanone derivatives (3a-d). These diketone compounds were reacted with varied benzylamines in acetic acid to obtain 2-benzyl-1-methylidene-3-aryl-1,2-dihydropyrazino[1,2-a]benzimidazole derivatives (4a-t). The structures of the obtained compounds were elucidated by using IR, H-1-NMR, C-13-NMR, MS spectral data and elemental analyses results. Anticancer activities of the selected compounds were investigated in National Cancer Institute, Bethesda, MD. 3c and 4n showed remarkable anticancer activity comparing with standard drugs, melphalan and cisplatin.
dc.identifier.citationDemirayak, Ş. ve Yurttas, L. (2014). Synthesis and anticancer activity of some 1,2,3-trisubstituted pyrazinobenzimidazole derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry, 29(6), 811-822. https://dx.doi.org/10.3109/14756366.2013.858142
dc.identifier.doi10.3109/14756366.2013.858142
dc.identifier.endpage822
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.issue6
dc.identifier.scopusqualityQ2
dc.identifier.startpage811
dc.identifier.urihttps://dx.doi.org/10.3109/14756366.2013.858142
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3104
dc.identifier.volume29
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subject1,2-Disubstituted Benzimidazole
dc.subjectAlpha,Beta-Unsaturated Carbonyl
dc.subjectAnticancer Activity
dc.subjectPyrazino[1,2-a]Benzimidazole
dc.titleSynthesis and anticancer activity of some 1,2,3-trisubstituted pyrazinobenzimidazole derivatives
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Demirayak, Seref-2014.pdf
Boyut:
1.69 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Eczacılık Fakültesi Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu