Preparation and evaluation of novel microemulsion-based hydrogels for dermal delivery of benzocaine

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dc.authorid0000-0002-3210-3747
dc.authorid0000-0003-2010-4918
dc.contributor.authorÜstündağ Okur, Neslihan
dc.contributor.authorÇağlar, Emre Şefik
dc.contributor.authorArpa, Muhammet Davut
dc.contributor.authorKarasulu, Hatice Yeşim
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:31Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:31Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.descriptionWOS: 000399500700007
dc.descriptionPubMed ID: 26738443
dc.description.abstractThe purpose of the current research was to prepare and evaluate the potential use of microemulsion-based hydrogel (MBH) formulations for dermal delivery of benzocaine (BZN). The pseudoternary-phase diagrams were constructed for various microemulsions composed of isopropyl myristate (IPM) as oil phase, Span 20, Tween 20, Tween 80, cremophor EL and cremophor RH40 as surfactants, ethanol as cosurfactant and distilled water as aqueous phase. Finally, concentration of BZN in microemulsions was 2% (w/w). The physicochemical properties, such as conductivity, viscosity, pH, droplet size, polydispersity index and zeta potential of microemulsions, were measured. Carbopol 940 was used to convert BZN-loaded microemulsions into gel form without affecting their structure. Furthermore, excised rat abdominal skin was used to compare permeation and penetration properties of BZN loaded M3 and M3BHs with BZN solution. According to ex vivo study results, BZN-loaded M3BH1 showed highest flux values and high release rate values, and furthermore, this gel formulation had low surfactant content. Finally, in order to learn the localization of formulations within the dermal penetration, formulations and BZN solution were labeled with red oil O and subjected to fluorescence observation. In conclusion, BZN-loaded MBHs could be offered as a promising strategy for dermal drug delivery.
dc.description.sponsorshipIstanbul Medipol University, Scientific Research Projects [2015/17]en_US
dc.description.sponsorshipThis study was supported by Istanbul Medipol University, Scientific Research Projects No: 2015/17.en_US
dc.identifier.citationÜstündağ Okur, N., Çağlar, E. Ş., Arpa, M. D. ve Karasulu, H. Y. (2017). Preparation and evaluation of novel microemulsion-based hydrogels for dermal delivery of benzocaine. Pharmaceutical Development and Technology, 22(4), 500-510. https://dx.doi.org/10.3109/10837450.2015.1131716
dc.identifier.doi10.3109/10837450.2015.1131716
dc.identifier.endpage510
dc.identifier.issn1083-7450
dc.identifier.issn1097-9867
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage500
dc.identifier.urihttps://dx.doi.org/10.3109/10837450.2015.1131716
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3668
dc.identifier.volume22
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofPharmaceutical Development and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBenzocaine
dc.subjectDermal Drug Delivery
dc.subjectCharacterization
dc.subjectFluorescence Observation
dc.subjectMicroemulsion
dc.subjectMicroemulsion-Based Hydrogel
dc.titlePreparation and evaluation of novel microemulsion-based hydrogels for dermal delivery of benzocaine
dc.typeArticle

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