The axon protective effects of syringic acid on ischemia/ereperfusion injury in a rat sciatic nerve model

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dc.authorid0000-0003-1367-1121
dc.contributor.authorTokmak, Mehmet
dc.contributor.authorŞehitoğlu, Müserref Hilal
dc.contributor.authorYüksel, Yasemin
dc.contributor.authorGüven, Mustafa
dc.contributor.authorAkman, Tarık
dc.contributor.authorAras, Adem Bozkurt
dc.contributor.authorYaka, Umut
dc.contributor.authorGömleksiz, Cengiz
dc.contributor.authorAlbayrak, Serdar Baki
dc.contributor.authorCoşar, Murat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:04:13Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:04:13Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.descriptionWOS: 000392042000017
dc.descriptionPubMed ID: 27593755
dc.description.abstractAIM: In the relevant literature, there is no experimental study that investigated the axon protective effects of syringic acid- a polyphenol compound- with an anti-oxidant capacity on ischemia/reperfusion injury. MATERIAL and METHODS: The rats were randomly divided into four groups: Control group (no medication or surgical procedure), Sham group, Syringic acid group, and Methyprednisolone (MP) Group. lschemia was achieved by abdominal aorta clamping and all animals were sacrificed 24 hours after ischemia. Harvested sciatic nerve segments were investigated histopathologically and for tissue biochemistry. RESULTS: lschemic fiber degeneration scores were found significantly lower in syringic acid and MP groups than sham group. Additionally, apoptosis-related cysteine peptidase caspase-3 immunostaining scores were lower in syringic acid and MP groups. Biochemically, superoxide dismutase and nuclear respiratory factor 1 values were significantly higher in syringic acid group compared to those of control and sham groups while malondialdehyde levels were significantly lower in the syringic acid group. CONCLUSION: Syringic acid reduces oxidative stress and axonal degeneration in rat sciatic nerve after ischemia/reperfusion injury. Therefore, syringic acid may play a role in the treatment of peripheral nerve injuries due to ischemia/reperfusion.
dc.identifier.citationTokmak, M., Şehitoğlu, M. H., Yüksel, Y., Güven, M., Akman, T., Aras, A. ... Coşar, M. (2017). The axon protective effects of syringic acid on ischemia/ereperfusion injury in a rat sciatic nerve model. Turkish Neurosurgery, 27(1), 124-132. https://dx.doi.org/10.5137/1019-5149.JTN.14656-15.5
dc.identifier.doi10.5137/1019-5149.JTN.14656-15.5
dc.identifier.endpage132
dc.identifier.issn1019-5149
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.startpage124
dc.identifier.urihttps://dx.doi.org/10.5137/1019-5149.JTN.14656-15.5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4015
dc.identifier.volume27
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neurosurgical Society
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAxon
dc.subjectSciatic Nerve
dc.subjectSyringic Acid
dc.subjectMethylprednisolone
dc.subjectReperfusion
dc.subjectMalondialdehyde
dc.subjectNuclear Respiratory Factor 1
dc.subjectSuperoxide Dismutase
dc.titleThe axon protective effects of syringic acid on ischemia/ereperfusion injury in a rat sciatic nerve model
dc.typeArticle

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