Synthesis of some 2,3,6,8-tetraarylimidazo[1,2-a]pyrazine derivatives by using either reflux or microwave irradiation method, and investigation their anticancer activities

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dc.contributor.authorKayagil, İsmail
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:03:41Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:03:41Z
dc.date.issued2011
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalı
dc.descriptionWOS: 000286528300002
dc.description.abstractIn this study, some 2,3,6,8-tetraarylimidazo[1,2-a]pyrazine derivatives were synthesized by reacting 1-(2-aryl-2-oxoethyl)-2-aryloyl-4,5-diarylimidazoles from 2-aryloyl-4,5-diarylimidazole and 2-bromoacetophenone derivatives with ammonium acetate in acetic acid by using the method that was previously developed and repeatedly tested in our studies. Structural elucidation of the compounds was performed by IR, (1)H-NMR, and MASS spectroscopic data and elemental analysis results. Anticancer activities of selected compounds were evaluated and the noticeable activity values were reported.
dc.identifier.citationKayagil, İ. ve Demirayak, Ş. (2011). Synthesis of some 2,3,6,8-tetraarylimidazo[1,2-a]pyrazine derivatives by using either reflux or microwave irradiation method, and investigation their anticancer activities. Turkish Journal of Chemistry, 35(1), 13-24. https://dx.doi.org/10.3906/kim-1005-649
dc.identifier.doi10.3906/kim-1005-649
dc.identifier.endpage24
dc.identifier.issn1300-0527
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.startpage13
dc.identifier.urihttps://dx.doi.org/10.3906/kim-1005-649
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3923
dc.identifier.volume35
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherScientific Technical Research Council Turkey
dc.relation.ispartofTurkish Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSubstituted Imidazoles
dc.subjectImidazo[1,2-a]pyrazines
dc.subjectMicrowave Irradiation
dc.subjectAnticancer Activity
dc.titleSynthesis of some 2,3,6,8-tetraarylimidazo[1,2-a]pyrazine derivatives by using either reflux or microwave irradiation method, and investigation their anticancer activities
dc.typeArticle

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