Evaluation of the effect of honey-containing chitosan/hyaluronic acid hydrogels on wound healing

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dc.authorid0000-0002-1693-9579
dc.contributor.authorŞalva, Emine
dc.contributor.authorAkdağ, Ahmet Enes
dc.contributor.authorAlan, Saadet
dc.contributor.authorArısoy, Sema
dc.contributor.authorAkbuğa, Fatma Jülide
dc.date.accessioned2023-12-12T11:54:14Z
dc.date.available2023-12-12T11:54:14Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.description.abstractThe 3D polymeric network structure of hydrogels imitates the extracellular matrix, thereby facilitating cell growth and differentiation. In the current study, chitosan/hyaluronic acid/honey coacervate hydrogels were produced without any chemicals or crosslinking agents and investigated for their wound-healing abilities. Chitosan/hyaluronic acid/honey hydrogels were characterized by FTIR, SEM, and rheology analysis. Moreover, their water content, water uptake capacities, and porosity were investigated. In FT-IR spectra, it was discovered that the characteristic band placement of chitosan with hyaluronic acid changed upon interacting with honey. The porosity of the honey-containing hydrogels (12%) decreased compared to those without honey (17%). Additionally, the water-uptake capacity of honey-containing hydrogels slightly decreased. Also, it was observed that hydrogels’ viscosity increased with the increased hyaluronic acid amount and decreased with the amount of honey. The adhesion and proliferation of fibroblast cells on the surface of hydrogel formulations were highest in honey-containing hydrogels (144%). In in vivo studies, wound healing was accelerated by honey addition. It has been demonstrated for the first time that honey-loaded chitosan-hyaluronic acid hydrogels, prepared without the use of toxic covalent crosslinkers, have potential for use in wound healing applications.
dc.identifier.citationŞalva, E., Akdağ, A. E., Alan, S., Arısoy, S. ve Akbuğa, F. J. (2023). Evaluation of the effect of honey-containing chitosan/hyaluronic acid hydrogels on wound healing. Gels, 9(11). https://dx.doi.org/10.3390/gels9110856
dc.identifier.doi10.3390/gels9110856
dc.identifier.issn2310-2861
dc.identifier.issue11
dc.identifier.pmid37998945
dc.identifier.scopus2-s2.0-85178089578
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.3390/gels9110856
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11985
dc.identifier.volume9
dc.identifier.wos001120261700001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkbuğa, Fatma Jülide
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofGelsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectChitosan
dc.subjectHoney
dc.subjectHyaluronic Acid
dc.subjectWound Healing
dc.subjectHydrogel
dc.subjectTissue Engineering
dc.titleEvaluation of the effect of honey-containing chitosan/hyaluronic acid hydrogels on wound healing
dc.typeArticle

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