Effects of melatonin and memantine administration on the learning and memory performances of hypoxic juvenile rat pups

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dc.authorid0000-0001-6494-8923
dc.contributor.authorElibol, Birsen
dc.contributor.authorŞahbaz, Çiğdem
dc.contributor.authorEyüboğlu, Siğnem
dc.contributor.authorÇevreli, Burcu
dc.contributor.authorKılıç, Ülkan
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned2021-05-03T10:30:42Z
dc.date.available2021-05-03T10:30:42Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractObjective: Herein, we aimed to investigate the long-term effects of neonatal hypoxia and the potential protective role of melatonin and memantine on the learning and memory. Methods: Seven-day-old rat underwent right carotid ligation, followed by hypoxia. Rat received Melatonin (MLT) (4 mg/kg), Memantine (MEM) (20 mg/kg), and MLT+MEM combination after hypoxia. We tested these rats for anxiety by elevated O-maze and for spatial learning and memory by Morris water maze (MWM) at postnatal day 45. Results: Hypoxia increased the level of anxiety compared to the control group (p=0.05) while treatment of MLT, MEM, and MLT+MEM ameliorated this effect. In addition, hypoxia produced significant decrease in spatial learning of the rats on the fourth day of training (P=0.05) and the percent time spent in the platform quadrant and the entrance frequencies to the platform quadrant compared to the control group (P=0.049 and P=0.023). Treatment of MLT, MEM, and MLT+MEM after hypoxia improved the performance of the rats at the third (P=0.686, P=0.876, P=0.977, respectively) and fourth day (P=0.738, P=0.553, P=0.789, respectively) of MWM training. The decrease in the percent time spent was ameliorated by the treatment of MLT (P=0.239), MEM (P=0.289), and MLT+MEM (P=0.567) compared to the control group. In addition, MLT treatment significantly increased the entrance frequency to the platform quadrant compared to the hypoxia group (P=0.020). Conclusion: Our data suggested that the MLT was more effective in the release of memory deficits from hypoxia-related damage. MLT might have a therapeutic value in improving hypoxic damage in the developing brain.
dc.identifier.citationElibol, B., Şahbaz, Ç., Eyüboğlu, S., Çevreli, B., Kılıç, Ü. ve Kılıç, E. (2020). Effects of melatonin and memantine administration on the learning and memory performances of hypoxic juvenile rat pups. Psychiatry and Behavioral Sciences, 10(3), 125-133. https://dx.doi.org/10.5455/PBS.20200604064021
dc.identifier.doi10.5455/PBS.20200604064021
dc.identifier.endpage133
dc.identifier.issn2636-834X
dc.identifier.issue3
dc.identifier.startpage125
dc.identifier.urihttps://dx.doi.org/10.5455/PBS.20200604064021
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6804
dc.identifier.volume10
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherYerküre Tanıtım ve Yayıncılık Hizmetleri A.Ş.
dc.relation.ispartofPsychiatry and Behavioral Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectNeonatal Hypoxia
dc.subjectLearning and Memory
dc.subjectMelatonin
dc.subjectMemantine
dc.subjectMorris Water Maze
dc.titleEffects of melatonin and memantine administration on the learning and memory performances of hypoxic juvenile rat pups
dc.typeArticle

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