In Vitro Antiviral Evaluations of Coldmix®: An Essential Oil Blend against SARS-CoV-2
| dc.authorid | 0000-0002-3412-0807 | |
| dc.contributor.author | Başer, Kemal Hüsnü Can | |
| dc.contributor.author | Karadağ, Ayşe Esra | |
| dc.contributor.author | Biltekin, Sevde Nur | |
| dc.contributor.author | Ertürk, Murat | |
| dc.contributor.author | Demirci, Fatih | |
| dc.date.accessioned | 2023-02-13T07:20:17Z | |
| dc.date.available | 2023-02-13T07:20:17Z | |
| dc.date.issued | 2023 | |
| dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı | |
| dc.description.abstract | Coldmix® is a commercially available Eucalyptus aetheroleum and, Abies aetheroleum blend for medicinal applications. In this present study, the in vitro antiviral potential of Coldmix®, and its major constituents 1,8-cineole and ?-pinene were evaluated by using the in vitro ACE2 enzyme inhibition assay as well as the direct contact test against SARS-CoV-2. The observed ACE2 enzyme inhibitory activity of Coldmix®, 1,8-cineole, and ?-pinene were 72%, 88%, and 80%, respectively; whereas in the direct contact test in the vapor phase, the destruction of the virus was 79.9% within 5 min and 93.2% in the 30th min, respectively. In a similar Coldmix® vapor phase setup using the in vitro cytotoxicity cell assay, E6 VERO healthy cells were experimentally not affected by toxicity. According to the promising initial antiviral results of Coldmix® and the individually tested constituents, detailed further in vivo evaluation using different virus classes is suggested. | |
| dc.identifier.citation | Başer, K. H. C., Karadağ, A. E. Biltekin, S. N., Ertürk, M. ve Demirci, F. (2023). In Vitro Antiviral Evaluations of Coldmix®: An Essential Oil Blend against SARS-CoV-2. Current Issues in Molecular Biology, 45(1), 677-684. https://dx.doi.org/10.3390/cimb45010045 | |
| dc.identifier.doi | 10.3390/cimb45010045 | |
| dc.identifier.endpage | 684 | |
| dc.identifier.issn | 1467-3037 | |
| dc.identifier.issn | 1467-3045 | |
| dc.identifier.issue | 1 | |
| dc.identifier.pmid | 36661531 | |
| dc.identifier.scopus | 2-s2.0-85147045206 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.startpage | 677 | |
| dc.identifier.uri | https://dx.doi.org/10.3390/cimb45010045 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/10421 | |
| dc.identifier.volume | 45 | |
| dc.identifier.wos | 000914538400001 | en_US |
| dc.identifier.wosquality | Q3 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.institutionauthor | Karadağ, Ayşe Esra | |
| dc.language.iso | en | |
| dc.publisher | NLM (Medline) | |
| dc.relation.ispartof | Current Issues in Molecular Biology | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | Attribution 4.0 International | * |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject | Abies | |
| dc.subject | ACE2 | |
| dc.subject | Antiviral | |
| dc.subject | Coronavirus | |
| dc.subject | Essential Oils | |
| dc.subject | Eucalyptus | |
| dc.title | In Vitro Antiviral Evaluations of Coldmix®: An Essential Oil Blend against SARS-CoV-2 | |
| dc.title.alternative | In vitro antiviral evaluations of coldmix(R): An essential oil blend against SARS-CoV-2 | |
| dc.type | Article |
