Role of erythropoietin and its receptor in the development of endometriosis in rats

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dc.authorid0000-0001-7702-2441
dc.authorid0000-0002-1079-8832
dc.authorid0000-0002-6895-8560
dc.authorid0000-0002-7059-1884
dc.authorid0000-0001-9416-7757
dc.authorid0000-0001-5134-1014
dc.authorid0000-0001-6494-8923
dc.contributor.authorGünal, Mehmet Yalçın
dc.contributor.authorOzansoy, Mehmet
dc.contributor.authorKılıç, Ülkan
dc.contributor.authorKeskin, İlknur
dc.contributor.authorÖzdemir, Ekrem Musa
dc.contributor.authorAslan, İsmail
dc.contributor.authorEren, Zehra
dc.contributor.authorErsavaş, Cenk
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:41Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:41Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Tıbbi Araştırma Merkezi (MEDİTAM)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.descriptionWOS: 000459590500009
dc.descriptionPubMed ID: 29916217
dc.description.abstractObjective: Besides its hematopoietic function, erythropoietin (EPO) may protect tissues from degenerative disorders. As such, EPO and its receptors were revealed in nonhematopoietic cells, including stromal and endometrial epithelial cells. However, the role of EPO in endometrial disorders is still unknown. Here, we aimed to examine the role of EPO and its receptor activation in the development of endometriosis in rats. Material and Methods: Animals were treated with EPO, darbepoietin (the synthetic form of EPO) or EPO's receptor activator, methoxy polyethylene glycol-epoetin beta (MIRCERA), after development of endometriosis. Endometriosis was induced by estrogen-administration following surgical attachment of endometrial surface on the inner abdominal wall. Treatments were started 3 weeks after induction of endometriosis and continued for the following 3 weeks. For the analysis of recurrence of endometriosis, additional analyses were conducted 3 weeks after cessation of treatments. Results: As compared with vehicle-treated animals, lesion size was reduced significantly and recurrence of endometriosis was not observed in all treatment groups. Histopathologic examination revealed that EPO and darbepoietin were more effective than MIRCERA- and vehicle-treated animals. Conclusion: Here we provide evidence that EPO is a promising candidate for the treatment of endometriosis. Our histopathologic results in particular indicate that EPO is more effective than its receptor activator MIRCERA in the development endometriosis.
dc.description.sponsorshipTurkish Academy of Sciences (TUBA)en_US
dc.description.sponsorshipThis work was funded by Turkish Academy of Sciences (TUBA). We would like to thank to Laboratory Technician Nurhayat Donek from Bezmialem University for help throughout this research.en_US
dc.identifier.citationGünal, M. Y., Ozansoy, M., Kılıç, Ü., Keskin, İ., Özdemir, E. M., Aslan, İ. … Kılıç, E. (2019). Role of erythropoietin and its receptor in the development of endometriosis in rats. Journal of the Turkhish-German Gynecological Association, 20(1), 41-46. https://dx.doi.org/10.4274/jtgga.galenos.2018.2018.0039
dc.identifier.doi10.4274/jtgga.galenos.2018.2018.0039
dc.identifier.endpage46
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.startpage41
dc.identifier.urihttps://dx.doi.org/10.4274/jtgga.galenos.2018.2018.0039
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1717
dc.identifier.volume20
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Yayıncılık
dc.relation.ispartofJournal of the Turkhish-German Gynecological Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEndometriosis
dc.subjectDarbepoietin
dc.subjectErythropoietin
dc.subjectMIRCERA
dc.subjectReceptor Activator
dc.titleRole of erythropoietin and its receptor in the development of endometriosis in rats
dc.typeArticle

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