3-Propionyl-thiazolidine-4-carboxylic acid ethyl esters: A family of antiproliferative thiazolidines

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dc.authorid0000-0001-6047-2796
dc.contributor.authorÖnen Bayram, Filiz Esra
dc.contributor.authorBuran, Kerem
dc.contributor.authorDurmaz, İrem
dc.contributor.authorBerk, Barkın
dc.contributor.authorÇetin-Atalay, Rengül
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:42Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:42Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.descriptionWOS: 000349700400008
dc.description.abstractCancer results from unregulated cell growth. Reactivating the process of the programmed cell death, i.e. apoptosis, is a classical anticancer therapeutic strategy. The apoptosis-inducing property of the (2RS,4R)-2-phenyl-3-propionyl-thiazolidine-4-carboxylic acid ethyl ester (ALC 67) molecule has recently been discovered. We analyzed in this study the impact of the phenyl moiety of this molecule on its biological activity by synthesizing and evaluating analogues where this substituent was replaced by a series of aromatic and aliphatic groups. The results demonstrated that the molecule's antiproliferative property resisted such modifications. Thus, in addition to developing a family of thiazolidine compounds with promising anticancer properties; our investigation revealed that the second position of the thiazolidine ring can be used either to tune the physicochemical properties of ALC67 or to introduce a fluorescent tag to the structure in order to track it in cells and determine its exact molecular mechanism of action.
dc.identifier.citationÖnen Bayram, F. E., Buran, K., Durmaz, İ., Berk, B. ve Çetin-Atalay, R. (2015). 3-Propionyl-thiazolidine-4-carboxylic acid ethyl esters: A family of antiproliferative thiazolidines. MedChemComm, 8(1), 90-93. https://dx.doi.org/10.1039/c4md00306c
dc.identifier.doi10.1039/c4md00306c
dc.identifier.endpage93
dc.identifier.issn2040-2503
dc.identifier.issn2040-2511
dc.identifier.issue1
dc.identifier.scopusqualityQ1
dc.identifier.startpage90
dc.identifier.urihttps://dx.doi.org/10.1039/c4md00306c
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3405
dc.identifier.volume6
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.relation.ispartofMedChemCommen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcid
dc.subjectEthyl
dc.subjectEster
dc.subjectAntiproliferative
dc.title3-Propionyl-thiazolidine-4-carboxylic acid ethyl esters: A family of antiproliferative thiazolidines
dc.typeArticle

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