Functional and anatomical dissection of feeding circuits

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dc.authorid0000-0002-3325-8820
dc.contributor.authorAtasoy, Deniz
dc.contributor.authorSternson, Scott M.
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:38:24Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:38:24Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractThis chapter reviews the application of new genetically encoded tools in feeding circuits that regulate appetite. Rapid activation and inhibition of agouti related peptide (AgRP) neurons conclusively established a causal role for rapid control of food intake. Chemogenetic activation of AgRP neurons using hM3Dq avoids the invasive protocols required for ChR2 activation. ChR2 distributes into axons, and selective optogenetic activation of AgRP neuron axon projection fields in distinct brain areas was used to examine their individual contribution to feeding behavior. Some of the brain areas targeted by AgRP neuron axon projections have been examined further for cell type specific control of appetite. Rodents with bed nucleus of stria terminalis (BNST) lesions show hyperphagia and obesity, indicating that reduced BNST output promotes feeding. pro-opiomelanocortin (POMC) neurons regulate feeding over longer timescales. parabrachial nucleus (PBN) neurons have a powerful inhibitory role on food intake, but their inhibition does not strongly elevate food intake.
dc.identifier.citationAtasoy, D. ve Sternson, S. M. (2016). Functional and anatomical dissection of feeding circuits. Neuroendocrinology of Appetite içinde (112-133. ss.). https://dx.doi.org/10.1002/9781118839317.ch6
dc.identifier.doi10.1002/9781118839317.ch6
dc.identifier.endpage133
dc.identifier.isbn9781118839317 -- 9781118839324
dc.identifier.scopusqualityN/A
dc.identifier.startpage112
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1590
dc.identifier.urihttps://dx.doi.org/10.1002/9781118839317.ch6
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofNeuroendocrinology of Appetiteen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAgouti Related Peptide Neurons
dc.subjectAppetite Regulation
dc.subjectBed Nucleus of Stria Terminalis
dc.subjectChemogenetic Tools
dc.subjectFeeding Circuits
dc.subjectObesity
dc.subjectOptogenetic Tools
dc.subjectParabrachial Nucleus Neurons
dc.subjectPro-Opiomelanocortin Neurons
dc.titleFunctional and anatomical dissection of feeding circuits
dc.typeBook Chapter

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