Synthesis, structure elucidation and determination of acid dissociation constant, tautomerism of pyrido [1,2-a] benzimidazole-2,4-dione

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dc.contributor.authorKayağil, İsmail
dc.contributor.authorTay, Naime Funda
dc.contributor.authorKonak, Hüseyin Yaşar
dc.contributor.authorİspir, Cihan
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:15Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:15Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.description.abstractThe first starting material, 1H-2-acetylbenzimidazole, 4, was synthesized by o-phenylenediamine, 1, and lactic acid solution, 2, in hydrochloric acid medium on the first step than, oxidation reaction was performed by CrO3 in acetic acid medium on the second step. The last starting material, ethyl 2-(2-acetylbenzimidazol-1-yl) acetate, 6, was synthesized by using first starting material, 4, ethyl 2-bromoacetate, 5, and K2 CO3 in acetone medium. The target compound, pyrido[1,2-a] benzimidazole-2,4-dione, 7, was synthesized by using the last starting material, 5, in sodium ethoxide medium. The compound, 7, can be found in two forms which are keto and enol which would be evaluated in this study. For the evaluation, it was performed some spectroscopic studies. In addition, it was evaluated experimentally obtained acidity constant, pKa value and tautomeric equilibrium of the compound, 7, by using ultraviolet-visible (UV-Vis) spectrophotometer. All of these studies have shown that the valid form of the compound, 7, is keto form.
dc.identifier.citationKayağil, İ., Tay, N. F., Konak, H. Y., İspir, C. ve Demirayak, Ş. (2016). Synthesis, structure elucidation and determination of acid dissociation constant, tautomerism of pyrido [1,2-a] benzimidazole-2,4-dione. Acta Pharmaceutica Sciencia, 54(1), 23-34. https://dx.doi.org/10.23893/1307-2080.APS.0542
dc.identifier.doi10.23893/1307-2080.APS.0542
dc.identifier.endpage34
dc.identifier.issn1307-2080
dc.identifier.issue1
dc.identifier.scopusqualityN/A
dc.identifier.startpage23
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1110
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.0542
dc.identifier.volume54
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversity of Istanbul
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcidity Constant
dc.subjectPKa Value
dc.subjectPyrido [1,2-a] Benzimidazole
dc.subjectTautomerism
dc.titleSynthesis, structure elucidation and determination of acid dissociation constant, tautomerism of pyrido [1,2-a] benzimidazole-2,4-dione
dc.typeArticle

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