The potential chemo-preventive roles of Malus domestica against the risk of colorectal cancer: A suggestive insight into clinical application

Basit Öğe Kaydı
dc.authorid0000-0002-7406-4600
dc.contributor.authorKöseoğlu, Aygül
dc.contributor.authorAl-Taie, Anmar
dc.date.accessioned2023-01-17T11:12:04Z
dc.date.available2023-01-17T11:12:04Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Klinik Eczacılık Ana Bilim Dalı
dc.description.abstractBiologically active compounds in fruit-derived ingredients, particularly phytochemicals, have significant potential to modulate and mitigate many pathological processes in the development of disease conditions, including cancer. Colorectal cancer (CRC) remains a major public health issue. Nonetheless, prevention is an important step in lowering the rate of mortality from this cancer. Currently, the link between apple consumption and improved health is becoming remarkably evident and is reported to be beneficial for human health. Phytochemicals, such as flavonoids and other polyphenol compounds extensively available in apple fruits, have well-known positive effects on health outcomes and the potential to combat and prevent the development of CRC, including antioxidant, anti-proliferative, and anticarcinogenic effects. This review describes the bioactive compounds derived from apple fruits, particularly the polyphenols and flavonoids, their proposed mechanisms responsible for their bioactive properties and health-promoting attributes that could provide potential chemo-preventive effects against the risk of CRC development. The conclusion of the review provides insights into the potential effects of apple-derived bioactive compounds and proposes the need for more clinical studies in large trials for future strategies regarding the valuable effects of apple phytochemicals, which might be therapeutic candidates in the campaign against CRC.
dc.identifier.citationKöseoğlu, A. ve Al-Taie, A. (2022). The potential chemo-preventive roles of Malus domestica against the risk of colorectal cancer: A suggestive insight into clinical application. Clinical Nutrition ESPEN, 52, 360-364. https://dx.doi.org/10.1016/j.clnesp.2022.09.017
dc.identifier.doi10.1016/j.clnesp.2022.09.017
dc.identifier.endpage364
dc.identifier.issn2405-4577
dc.identifier.pmid36513476
dc.identifier.scopus2-s2.0-85139365716
dc.identifier.scopusqualityQ2
dc.identifier.startpage360
dc.identifier.urihttps://dx.doi.org/10.1016/j.clnesp.2022.09.017
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10319
dc.identifier.volume52
dc.identifier.wos000907176300001en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKöseoğlu, Aygül
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofClinical Nutrition ESPENen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectApple
dc.subjectChemo-Prevention
dc.subjectColorectal Cancer
dc.subjectFlavonoids
dc.subjectMalus Domestica
dc.subjectPolyphenols
dc.titleThe potential chemo-preventive roles of Malus domestica against the risk of colorectal cancer: A suggestive insight into clinical application
dc.typeReview Article

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Koseoglu-Aygul-2022.pdf
Boyut:
613.42 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Eczacılık Fakültesi Diğer Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu