Chemical characterization and multidirectional biological effects of different solvent extracts of arum elongatum: in vitro and in silico approaches

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dc.authorid0000-0002-3412-0807
dc.contributor.authorFawzi Mahomoodally, Mohamad
dc.contributor.authorZengin, Gökhan
dc.contributor.authorRoumita, Seebaluck-Sandoram
dc.contributor.authorCaprioli, Giovanni
dc.contributor.authorMustafa, Ahmed M.
dc.contributor.authorPiatti, Diletta
dc.contributor.authorYıldıztugay, Evren
dc.contributor.authorAk, Güneş
dc.contributor.authorKaradağ, Ayşe Esra
dc.contributor.authorKhalid, Asaad
dc.contributor.authorAbdalla, Ashraf N.
dc.contributor.authorİbrahim Uba, Abdullahi
dc.contributor.authorDemirci, Fatih
dc.date.accessioned2023-05-31T07:32:15Z
dc.date.available2023-05-31T07:32:15Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı
dc.description.abstractArum elongatum (Araceae) is widely used traditionally for the treatment of abdominal pain, arterial hypertension, diabetes mellitus, rheumatism and hemorrhoids. This study investigated the antioxidant properties, individual phenolic compounds, total phenolic and total flavonoid contents (HPLC/MS analysis), reducing power and metal chelating effects of four extracts obtained from A. elongatum (ethyl acetate (EA), methanol (MeOH), methanol/water (MeOH/water) and infusion). The inhibitory activity of the extracts were also determined against acetylcholinesterase, butyrylcholinesterase, tyrosinase, amylase and glucosidase enzymes. The MeOH/water extracts contained the highest amount of phenolic contents (28.85 mg GAE/g) while the highest total flavonoid content was obtained with MeOH extract (36.77 mg RE/g). MeOH/water demonstrated highest antioxidant activity against DPPH? radical at 38.90 mg Trolox equivalent per gram. The infusion extract was the most active against ABTS+? (133.08 mg TE/g). MeOH/water extract showed the highest reducing abilities with the CUPRAC value of 102.22 mg TE/g and the FRAP value of 68.50 mg TE/g. A strong metal chelating effect was observed with MeOH/water extract (35.72 mg EDTAE/g). The PBD values of the extracts ranged from 1.01 to 2.17 mmol TE/g. EA extract displayed the highest inhibitory activity against AChE (2.32 mg GALAE/g), BChE (3.80 mg GALAE/g), ?-amylase (0.56 mmol ACAE/g) and ?-glucosidase (9.16 mmol ACAE/g) enzymes. Infusion extract was the most active against tyrosinase enzyme with a value of 83.33 mg KAE/g. A total of 28 compounds were identified from the different extracts. The compounds present in the highest concentration were chlorogenic acids, 4-hydroxybenzoic acid, caffeic acid, p-coumaric acid, ferulic acid, isoquercitrin, delphindin 3,5-diglucoside, kaempferol-3-glucoside and hyperoside. The biological activities of A. elongatum extracts could be due to the presence of compounds such as gallic acid, chlorogenic acids, ellagic acid, epicatechin, catechin, kaempferol, 4-hydroxybenzoic acid, caffeic acid, p-coumaric acid, ferulic acid, quercetin, isoquercitrin, and hyperoside. Extracts of A. elongatum showed promising biological activities which warrants further investigations in an endeavor to develop biopharmaceuticals.
dc.identifier.citationFawzi Mahomoodally, M., Zengin, G., Roumita, S.-S., Caprioli, G., Mustafa, A. M., Piatti, D. ... Demirci, F. (2023). Chemical characterization and multidirectional biological effects of different solvent extracts of arum elongatum: in vitro and in silico approaches. Chemistry and Biodiversity, 20(4). https://doi.org/10.1002/cbdv.202201181
dc.identifier.doi10.1002/cbdv.202201181
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue4
dc.identifier.pmid36891864
dc.identifier.scopus2-s2.0-85150664088
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/cbdv.202201181
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10998
dc.identifier.volume20
dc.identifier.wos000955552300001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaradağ, Ayşe Esra
dc.language.isoen
dc.publisherWiley-VCH Verlag
dc.relation.ispartofChemistry and Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectArum
dc.subjectPhenolic Composition
dc.subjectBioactive Agent
dc.subjectNatural Enzyme Inhibitors
dc.titleChemical characterization and multidirectional biological effects of different solvent extracts of arum elongatum: in vitro and in silico approaches
dc.typeArticle

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