qEEG methods to probe abnormal brain rhythms related to quiet vigilance in patients with dementia due to Alzheimer’s, Parkinson’s, and lewy body diseases

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dc.authorid0000-0002-0860-0524
dc.contributor.authorBabiloni, Claudio
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorYener, Görsev
dc.contributor.authordel Percio, Claudio
dc.date.accessioned2023-12-12T06:49:55Z
dc.date.available2023-12-12T06:49:55Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.description.abstractHere, we discuss relevant literature findings on abnormal resting-state scalp-recorded electroencephalographic (rsEEG) rhythms in old patients with severe cognitive deficits and disabilities in activities of daily living (i.e., dementia) due to Alzheimer’s (ADD), Parkinson’s (PDD), and Lewy body (DLB) neurodegenerative diseases. Furthermore, we described a modern quantitative EEG (qEEG) methodology to explore those rhythms and related vigilance disorders. The reviewed findings unveil consistent abnormalities in topographic and frequency (most in <12 Hz) features of the rsEEG rhythms recorded in ADD, PDD, and DLB patients, probably reflecting altered neurophysiological oscillatory mechanisms of synchronization and functional connectivity in neural brain populations underpinning the regulation and maintenance of the quiet vigilance. The proposed qEEG methodology showed significant differences in the posterior cortical sources of rsEEG alpha rhythms at individual frequencies among small groups of ADD, PDD, and DLB patients. Although the above abnormalities may have a limited diagnostic value at the individual level, not specifically reflecting the neuropathological processes underlying ADD, PDD, and DLB, they have significant heuristic and clinical relevance. Namely, the rsEEG readouts at the alpha frequencies unveiled the altered neurophysiological oscillatory mechanisms responsible for vigilance disorders in ADD, PDD, and DLB patients and may be used as pathophysiological biomarkers to evaluate the efficacy of (non)pharmacological interventions to treat those disorders. We recommend using the present qEEG methodology in longitudinal rsEEG studies carried out in ADD, PDD, and DLB patients to explore the abnormalities in the rsEEG biomarkers of vigilance dysregulations during the disease progression.
dc.identifier.citationBabiloni, C., Güntekin, B., Yener, G. ve del Percio, C. (2024). qEEG methods to probe abnormal brain rhythms related to quiet vigilance in patients with dementia due to Alzheimer’s, Parkinson’s, and lewy body diseases. Neuromethods içinde (67-89. ss.). Humana Press Inc. https://dx.doi.org/10.1007/978-1-0716-3545-2_4
dc.identifier.doi10.1007/978-1-0716-3545-2_4
dc.identifier.endpage89
dc.identifier.issn0893-2336
dc.identifier.scopus2-s2.0-85178118759
dc.identifier.scopusqualityN/A
dc.identifier.startpage67
dc.identifier.urihttps://dx.doi.org/10.1007/978-1-0716-3545-2_4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11981
dc.identifier.volume206
dc.indekslendigikaynakScopus
dc.institutionauthorGüntekin, Bahar
dc.language.isoen
dc.publisherHumana Press Inc.
dc.relation.ispartofNeuromethodsen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAlzheimer’s Disease Dementia (ADD)
dc.subjectCortical Functional Connectivity
dc.subjectDementia With Lewy Bodies (DLB)
dc.subjectMild Cognitive Impairment (MCI)
dc.subjectNeural Synchronization
dc.subjectParkinson’s Disease Dementia (PDD)
dc.subjectResting-State Eyes-Closed Electroencephalographic (EEG) Rhythms
dc.titleqEEG methods to probe abnormal brain rhythms related to quiet vigilance in patients with dementia due to Alzheimer’s, Parkinson’s, and lewy body diseases
dc.typeBook Chapter

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