Survival outcomes of patients with oligometastatic non-small cell lung cancer who were treated with radical therapy: A multicenter analysis

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dc.authorid0000-0003-2715-4002
dc.authorid0000-0002-0443-6966
dc.authorid0000-0002-0077-6971
dc.authorid0000-0001-7934-7039
dc.contributor.authorAçıkgöz, Özgür
dc.contributor.authorBilici, Ahmet
dc.contributor.authorTataroğlu Özyükseler, Deniz
dc.contributor.authorGöktaş Aydin, Sabin
dc.contributor.authorSelçukbiricik, Fatih
dc.contributor.authorRzazade, Rashad
dc.contributor.authorÖlmez, Ömer Fatih
dc.contributor.authorBaşak Çağlar, Hale
dc.date.accessioned2023-09-12T12:05:54Z
dc.date.available2023-09-12T12:05:54Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground/aim: Oligometastatic disease for nonsmall cell lung cancer (NSCLC) patients is generally thought to represent a better prognosis with a quieter biology, limited number of disease sites and long-term disease control. In this study, we aimed to determine the efficacy of radical treatment options for patients with oligometastatic NSCLC. Materials and methods: This retrospective trial included totally 134 patients with oligometastatic NSCLC. The presence of oncodriver mutation, tumor stages and nodal status, the number of metastases and involved metastatic site, treatment of primary tumor and oligometastasis, response rate, overall survival (OS) and progression-free survival (PFS) were evaluated. Results: Of 134 patients 66.4% were defined as adenocarcinoma, 26.1% were squamous cell carcinoma and 7.5% of patients were in other histology. Based on the treatment of primary tumor, in 36 patients (26.9%) curative surgery has undergone, in addition, 19 (14.2%) patients were received chemotherapy, 73 (54.5%) were treated with chemoradiotherapy, while immunotherapy and targeted therapy were used in 1 (0.7%) and 2 (1.4%), respectively. The preferred treatment for oligometastatic lesions were SBRT in 72.4% of patients, surgery in 10.5%, and both SBRT and surgery in 17.1% of patients. At the median follow up of 31.3 months (range: 9.5–48.5), the median PFS and OS times were 17 and 24.4 months, respectively. Moreover, OS-2 after progression was also 7.2 months. Conclusion: Based on our real-life experience, we demonstrated a significant correlation between good response to first treatment and survival in oligometastatic disease, we also understand that local ablative treatment modalities prolong and also delay both OS and PFS in oligometastatic NSCLC patients OS-2.
dc.identifier.citationAçıkgöz, Ö., Bilici, A., Tataroğlu Özyükseler, D., Göktaş Aydin, S., Selçukbiricik, F., Rzazade, R. ... Başak Çağlar, H. (2023). Survival outcomes of patients with oligometastatic non-small cell lung cancer who were treated with radical therapy: A multicenter analysis. Turkish Journal of Medical Sciences, 53(4), 949-961. https://dx.doi.org/10.55730/1300-0144.5659
dc.identifier.doi10.55730/1300-0144.5659
dc.identifier.endpage961
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85168797683
dc.identifier.scopusqualityQ3
dc.identifier.startpage949
dc.identifier.trdizinid1194046
dc.identifier.urihttps://dx.doi.org/10.55730/1300-0144.5659
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11416
dc.identifier.volume53
dc.identifier.wos001166710900012en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorAçıkgöz, Özgür
dc.institutionauthorBilici, Ahmet
dc.institutionauthorGöktaş Aydın, Sabin
dc.institutionauthorÖlmez, Ömer Fatih
dc.language.isoen
dc.publisherTurkiye Klinikleri
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectOligometastasis
dc.subjectNonsmall Cell Lung Cancer
dc.subjectRadical Treatment
dc.subjectTargeted Therapy
dc.titleSurvival outcomes of patients with oligometastatic non-small cell lung cancer who were treated with radical therapy: A multicenter analysis
dc.typeArticle

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