Assessment of 25-OH vitamin D levels and abnormal blood pressure response in female patients with cardiac syndrome X

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dc.authorid0000-0002-4607-5724
dc.authorid0000-0001-9975-5507
dc.contributor.authorBabür Güler, Gamze
dc.contributor.authorGüler, Ekrem
dc.contributor.authorHatipoğlu, Suzan
dc.contributor.authorGüneş, Hacı Murat
dc.contributor.authorGeçmen, Çetin
dc.contributor.authorDemir, Gültekin Günhan
dc.contributor.authorBarutçu, İrfan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:37:04Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:37:04Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractObjective: Vitamin D deficiency is associated with coronary artery disease, hypertension, heart failure, endothelial dysfunction, and metabolic syndrome. The pathophysiology of cardiac syndrome X (CSX) involves many pathways that are influenced by vitamin D levels. This study aimed to investigate the relationship between vitamin D deficiency and abnormal blood pressure response to exercise in patients with CSX. Methods: This was a cross-sectional and observational study. Fifty females with normal epicardial coronary arteries who presented with typical symptoms of rest or effort angina and 41 healthy age-matched female controls, were included. Patients with cardiomyopathy, severe valvular disease, congenital heart disease, and left ventricular hypertrophy were excluded. All patients underwent stress electrocardiography examination and 25-hydroxy (OH) vitamin D level measurements. Results: Levels of 25-OH vitamin D were significantly lower in CSX patients (9.8±7.3 ng/mL vs. 18.1±7.9 ng/mL; p<0.001). Systolic blood pressure (SBP) (188±15 mm Hg vs. 179±17 mm Hg; p=0.013) and diastolic blood pressure (DBP) (98±9 mm Hg vs. 88±9 mm Hg; p<0.001) during peak exercise were higher in CSX patients. Levels of 25-OH vitamin D were negatively correlated with peak SBP (r=–0.310, p=0.004) and peak DBP (r=–0.535, p<0.001) during exercise. To discard the multicollinearity problem, two different models were used for multivariate analyses. In the first model, metabolic equivalents (METs) (p=0.003) and 25-OH vitamin D levels (p=0.001) were independent predictors. METs (p=0.007), 25-OH vitamin D levels (p=0.008), and peak DBP were determined as independent predictors in the second multivariate model. Conclusion: In patients with CSX, 25-OH vitamin D levels were lower than those in controls; moreover, 25-OH vitamin D deficiency was also associated with higher levels of peak DBP during exercise.
dc.identifier.citationBabür Güler, G., Güler, E., Hatipoğlu, S., Güneş, H. M., Geçmen, Ç., Demir, G. G. ... Barutçu, İ. (2016). Assessment of 25-OH vitamin D levels and abnormal blood pressure response in female patients with cardiac syndrome X. Anatolian Journal of Cardiology, 16(12), 961-966.
dc.identifier.doi10.14744/AnatolJCardiol.2016.6862
dc.identifier.endpage966
dc.identifier.issn2149-2263
dc.identifier.issue12
dc.identifier.scopusqualityQ3
dc.identifier.startpage961
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1323
dc.identifier.urihttps://dx.doi.org/10.14744/AnatolJCardiol.2016.6862
dc.identifier.volume16
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Society of Cardiology
dc.relation.ispartofAnatolian Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject25-OH Vitamin D
dc.subjectAbnormal Blood Pressure Response
dc.subjectCardiac Syndrome X
dc.titleAssessment of 25-OH vitamin D levels and abnormal blood pressure response in female patients with cardiac syndrome X
dc.typeArticle

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