Phytochemical compounds loaded to nanocarriers as potential therapeutic substances for alzheimer’s disease-could they be effective?

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dc.authorid0000-0002-3412-0807
dc.authorid0000-0003-0052-3648
dc.contributor.authorPolat, Derya Çiçek
dc.contributor.authorKaradağ, Ayşe Esra
dc.contributor.authorParlar Köprülü, Rabia Edibe
dc.contributor.authorKarantas, Ioannis D.
dc.contributor.authorMutlu, Gökçe
dc.contributor.authorÇağlar, Emre Şefik
dc.contributor.authorOkur, Mehmet Evren
dc.contributor.authorÜstündağ Okur, Neslihan
dc.contributor.authorSiafaka, Panoraia I.
dc.date.accessioned2022-11-04T12:44:29Z
dc.date.available2022-11-04T12:44:29Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractAlzheimer's disease accounts for a high percentage of dementia cases in elderly individuals. This type of brain disease is caused by damage to the brain cells affecting the ability of the patients to communicate, as well as their thinking, behavior, and feelings. Although numerous research laboratories focus on advancements in treating Alzheimer's disease, the currently approved pharmacological approaches seem to only alleviate the symptoms. Consequently, there is an urgent need for alternative pharmacological options that can prevent the progressive impairment of neurons. Natural substances were used in ancient times to treat various disorders given their biological activities such as antioxidant, anti-inflammatory, and antiapoptotic properties. Besides, their cost-effectiveness and accessibility to anyone who needs them are their most significant characteristics. Therefore, the possible use of phytochemical compounds for the possible management or even prevention of Alzheimer's disease is currently under investigation. This review article summarizes the present status of Alzheimer's disease diagnosis and underlying mechanisms, the potential phytochemicals and their carriers, along with future perspectives. In the future, natural substances can play a role as an adjunct therapy for neurodegenerative forms of dementia, such as Alzheimer's disease.
dc.identifier.citationPolat, D. Ç., Karadağ, A. E., Parlar Köprülü, R. E., Karantas, I. D., Mutlu, G., Çağlar, E. Ş. ... Siafaka, P. I. (2022). Phytochemical compounds loaded to nanocarriers as potential therapeutic substances for alzheimer’s disease-could they be effective? Current Pharmaceutical Design, 28(30), 2437-2460. https://dx.doi.org/10.2174/1381612828666220411104128
dc.identifier.doi10.2174/1381612828666220411104128
dc.identifier.endpage2460
dc.identifier.issn1381-6128
dc.identifier.issn1873-4286
dc.identifier.issue30
dc.identifier.pmid35410592
dc.identifier.scopus2-s2.0-85138623152
dc.identifier.scopusqualityQ2
dc.identifier.startpage2437
dc.identifier.urihttps://dx.doi.org/10.2174/1381612828666220411104128
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9929
dc.identifier.volume28
dc.identifier.wos000870178700001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaradağ, Ayşe Esra
dc.institutionauthorParlar Köprülü, Rabia Edibe
dc.language.isoen
dc.publisherBentham Science Publishers
dc.relation.ispartofCurrent Pharmaceutical Designen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlzheimer’s Disease
dc.subjectPhytochemicals
dc.subjectCarriers
dc.subjectNanotechnology
dc.subjectAdjunct Therapy
dc.subjectBiological Activities
dc.titlePhytochemical compounds loaded to nanocarriers as potential therapeutic substances for alzheimer’s disease-could they be effective?
dc.typeReview Article

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