Evaluation of in vitro antiprotozoal activity of Ajuga laxmannii and its secondary metabolites

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dc.contributor.authorAtay, İrem
dc.contributor.authorKırmızıbekmez, Hasan
dc.contributor.authorKaiser, Marcel
dc.contributor.authorAkaydın, Galip
dc.contributor.authorYeşilada, Erdem
dc.contributor.authorTaşdemir, Deniz
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:31Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:31Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı
dc.descriptionWOS: 000382572400035
dc.descriptionPubMed ID: 26734766
dc.description.abstractContext Some Ajuga L. (Lamiaceae) species are traditionally used for the treatment of malaria, as well as fever, which is a common symptom of many parasitic diseases.Objective In the continuation of our studies on the identification of antiprotozoal secondary metabolites of Turkish Lamiaceae species, we have investigated the aerial parts of Ajuga laxmannii.Materials and methods The aerial parts of A. laxmannii were extracted with MeOH. The H2O subextract was subjected to polyamide, C-18-MPLC and SiO2 CCs to yield eight metabolites. The structures of the isolates were elucidated by NMR spectroscopy and MS analyses. The extract, subextracts as well as the isolates were tested for their in vitro antiprotozoal activities against Plasmodium falciparum, Trypanasoma brucei rhodesiense, T. cruzi and Leishmania donovani at concentrations of 90-0.123g/mL.Results Two iridoid glycosides harpagide (1) and 8-O-acetylharpagide (2), three o-coumaric acid derivatives cis-melilotoside (3), trans-melilotoside (4) and dihydromelilotoside (5), two phenylethanoid glycosides verbascoside (6) and galactosylmartynoside (7) and a flavone-C-glycoside, isoorientin (8) were isolated. Many compounds showed moderate to good antiparasitic activity, with isoorientin (8) displaying the most significant antimalarial potential (an IC50 value of 9.7g/mL).Discussion and conclusion This is the first report on the antiprotozoal evaluation of A. laxmannii extracts and isolates. Furthermore, isoorientin and dihydromelilotoside are being reported for the first time from the genus Ajuga.
dc.identifier.citationAtay, İ., Kırmızıbekmez, H., Kaiser, M., Akaydın, G., Yeşilada, E. ve Taşdemir, D. (2016). Evaluation of in vitro antiprotozoal activity of Ajuga laxmannii and its secondary metabolites. Pharmaceutical Biology, 54(9), 1808-1814. https://dx.doi.org/10.3109/13880209.2015.1129542
dc.identifier.doi10.3109/13880209.2015.1129542
dc.identifier.endpage1814
dc.identifier.issn1388-0209
dc.identifier.issn1744-5116
dc.identifier.issue9
dc.identifier.scopusqualityQ1
dc.identifier.startpage1808
dc.identifier.urihttps://dx.doi.org/10.3109/13880209.2015.1129542
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3667
dc.identifier.volume54
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofPharmaceutical Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntiprotozoal Activity
dc.subjectFlavonoid
dc.subjectIridoid Glycosides
dc.subjectIsoorientin
dc.subjectLamiaceae
dc.subjectPlasmodium
dc.titleEvaluation of in vitro antiprotozoal activity of Ajuga laxmannii and its secondary metabolites
dc.typeArticle

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