Phytochemical screening, biological evaluation, anatomical, and morphological investigation of Ferula tingitana L. (Apiaceae)

Basit Öğe Kaydı
dc.authorid0000-0002-6869-8703
dc.contributor.authorKarakaya, Songül
dc.contributor.authorYuca, Hafize
dc.contributor.authorYılmaz, Gülderen
dc.contributor.authorAydın, Bilge
dc.contributor.authorTekman, Enes
dc.contributor.authorEkşi, Gülnur
dc.contributor.authorBona, Mehmet
dc.contributor.authorGöger, Gamze
dc.contributor.authorKaradayı, Mehmet
dc.contributor.authorGülşahin, Yusuf
dc.contributor.authorÖztürk, Gözde
dc.contributor.authorDemirci, Betül
dc.contributor.authorGüvenalp, Zühal
dc.date.accessioned2024-02-14T12:30:46Z
dc.date.available2024-02-14T12:30:46Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı
dc.description.abstractFerula tingitana L. is a high perennial plant and its leaf is an alternate arrangement and yellow, and its flowers are unisexual like other Apiaceae. It has been used as a spice and for various medicinal purposes in the Mediterranean region. The paper reports antidiabetic, antimicrobial, anticholinesterase, antioxidant, and genotoxic activities of leaves, flowers, stems, and fruits methanol extracts of F. tingitana. Also, quantitative determination of some secondary metabolites was also analyzed by LC-MS/MS. Moreover, chemical composition of essential oils was analyzed. Consequently, anatomical, and morphological properties of plant were investigated. Germacrene D (23.6%), 1,3,5-trimethylbenzene (18.4%), and alpha-pinene (50.0%) were found as the main compounds in flower, leaf, and stem oils, respectively. The cortex in stem, pedicel, and fruit is characterized by angular collenchyma cells and a distinct cambium layer. 6 compounds (quinic acid, fumaric acid, keracyanin chloride, cyanidin-3-O-glucoside, chlorogenic acid, hesperidin) were observed in samples. Leaf extract showed anticholinesterase activity. Leaf and flower extracts showed the highest % inhibition value on ABTS(center dot+) and DPPH center dot. Leaf extract has the strongest antioxidant effect because it is rich in total phenolic contents. All extracts of F. tingitana were found generally effective against C. albicans. Stem extract was found effective against E. coli and flower extract was found more effective against S. enterica and C. albicans. Bacterial genotoxicity results showed that extracts did not have genotoxic activity on tester strains S. typhimurium and E. coli WP2uvrA. Thus, it revealed that extracts were genotoxic-ally safe at applied concentrations up to 3 mg/plate.
dc.description.sponsorshipTurkish Scientific and Technical Research Council (TUBITAK)en_US
dc.identifier.citationKarakaya, S., Yuca, H., Yılmaz, G., Aydın, B., Tekman, E., Ekşi, G. ... Güvenalp, Z. (2023). Phytochemical screening, biological evaluation, anatomical, and morphological investigation of Ferula tingitana L. (Apiaceae). Protoplasma, 260(6), 1581-1601. https://dx.doi.org/10.1007/s00709-023-01874-2
dc.identifier.doi10.1007/s00709-023-01874-2
dc.identifier.endpage1601
dc.identifier.issn0033-183X
dc.identifier.issn1615-6102
dc.identifier.issue6
dc.identifier.pmid37338647
dc.identifier.scopus2-s2.0-85162196138
dc.identifier.scopusqualityQ1
dc.identifier.startpage1581
dc.identifier.urihttps://dx.doi.org/10.1007/s00709-023-01874-2
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12279
dc.identifier.volume260
dc.identifier.wos001015543600003en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorEkşi, Gülnur
dc.language.isoen
dc.publisherSpringer Wien
dc.relation.ispartofProtoplasmaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectFerula Tingitana
dc.subjectAntioxidant
dc.subjectAnticholinesterase
dc.subjectAntidiabetic
dc.subjectAnatomical
dc.subjectMorphological
dc.titlePhytochemical screening, biological evaluation, anatomical, and morphological investigation of Ferula tingitana L. (Apiaceae)
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Eksi-Gulnur-2023.pdf
Boyut:
3.9 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Eczacılık Fakültesi Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu