Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne

Arpa, Muhammet Davut; Doğan, Nilay; Gündüz, Melisa; Karavelioğlu, Elçin Su; Erim, Ümit Can

Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne

dc.authorid	0000-0001-9290-2404
dc.authorid	0009-0006-3223-0275
dc.authorid	0000-0002-4121-588X
dc.contributor.author	Arpa, Muhammet Davut
dc.contributor.author	Doğan, Nilay
dc.contributor.author	Gündüz, Melisa
dc.contributor.author	Karavelioğlu, Elçin Su
dc.contributor.author	Erim, Ümit Can
dc.date.accessioned	2024-03-08T10:00:05Z
dc.date.available	2024-03-08T10:00:05Z
dc.date.issued	2024
dc.department	İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.department	İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalı
dc.description.abstract	Acne is an inflammatory or non-inflammatory disease that can be seen at every stage of human life and affects daily life both physically and psychologically. In the topical treatment of acne, substances with different pharmacological effects such as benzoyl peroxide, isotretinoin, azelaic acid (AZE), and erythromycin are used alone or in combination. AZE cream (20%) has been frequently preferred in the treatment of mild and moderate acne in recent years. However, since AZE has poor solubility in water, its low permeability problems may occur. In this study, the soluble form of AZE was obtained by forming an inclusion complex of AZE with 2-hydroxypropyl ?-cyclodextrin (H?C). In addition, the gel formulation, which generally exhibits higher permeability properties than oily formulations, was prepared using hydroxypropyl methylcellulose (HPMC). The formation of the inclusion complex was confirmed by NMR, XRD, DSC, and FTIR analyses. As a result of the characterization studies of the hydrogel formulations, it was determined that they had pseudoplastic flow and their viscosity was approximately 220 Pa.s. In drug release studies conducted with the dialysis bag method, it was found that the AZE-H?C hydrogel formulations had a similar cumulative release percent as H?C-free hydrogels but showed a higher cumulative release percent than the commercial cream (Azelderm, Orva, Türkiye). It was proven that the drug release of the formulations that exhibit a release profile in accordance with Higuchi kinetics was different from Azelderm according to difference (f1) and similarity (f2) factors.
dc.identifier.citation	Arpa, M. D., Doğan, N., Gündüz, M., Karavelioğlu, E. S. ve Erim, Ü. C. (2024). Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne. Journal of Research in Pharmacy, 28(1), 177-190. https://dx.doi.org/10.29228/jrp.686
dc.identifier.doi	10.29228/jrp.686
dc.identifier.endpage	190
dc.identifier.issn	2630-6344
dc.identifier.issue	1
dc.identifier.scopus	2-s2.0-85185438413
dc.identifier.scopusquality	Q3
dc.identifier.startpage	177
dc.identifier.uri	https://dx.doi.org/10.29228/jrp.686
dc.identifier.uri	https://hdl.handle.net/20.500.12511/12350
dc.identifier.volume	28
dc.identifier.wos	001167297700014	en_US
dc.identifier.wosquality	N/A
dc.indekslendigikaynak	Web of Science
dc.indekslendigikaynak	Scopus
dc.institutionauthor	Arpa, Muhammet Davut
dc.institutionauthor	Doğan, Nilay
dc.institutionauthor	Gündüz, Melisa
dc.institutionauthor	Karavelioğlu, Elçin Su
dc.institutionauthor	Erim, Ümit Can
dc.language.iso	en
dc.publisher	Marmara University
dc.relation.ispartof	Journal of Research in Pharmacy	en_US
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Acne
dc.subject	Azelaic Acid
dc.subject	Cyclodextrin
dc.subject	HPMC
dc.subject	Hydrogel
dc.title	Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne
dc.type	Article