Clinical characteristics, disease activity, functional status, and quality of life results of patients with psoriatic arthritis using biological and conventional synthetic disease-modifying antirheumatic drugs

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dc.authorid0000-0002-1111-3110
dc.contributor.authorKeskin, Yaşar
dc.contributor.authorNas, Kemal
dc.contributor.authorKılıç, Erkan
dc.contributor.authorSargın, Betül
dc.contributor.authorAcer Kasman, Sevtap
dc.contributor.authorAlkan, Hakan
dc.contributor.authorŞahin, Nilay
dc.contributor.authorCengiz, Gizem
dc.contributor.authorCüzdan, Nihan
dc.contributor.authorAlbayrak Gezer, İlknur
dc.contributor.authorKeskin, Dilek
dc.contributor.authorMülkoğlu, Cevriye
dc.contributor.authorReşorlu, Hatice
dc.contributor.authorAtaman, Şebnem
dc.contributor.authorBal, Ajda
dc.contributor.authorDuruöz, Mehmet Tuncay
dc.contributor.authorKüçükakkaş, Okan
dc.contributor.authorYurdakul, Ozan Volkan
dc.contributor.authorAlkan Melikoğlu, Meltem
dc.contributor.authorAydın, Yıldıray
dc.contributor.authorAyhan, Figen
dc.contributor.authorBodur, Hatice
dc.contributor.authorÇalış, Mustafa
dc.contributor.authorÇapkın, Erhan
dc.contributor.authorDevrimsel, Gül
dc.contributor.authorGök, Kevser
dc.contributor.authorHizmetli, Sami
dc.contributor.authorKamanlı, Ayhan
dc.contributor.authorEcesoy, Hilal
dc.contributor.authorKutluk, Öznur
dc.contributor.authorŞen, Nesrin
dc.contributor.authorŞendur, Ömer Faruk
dc.contributor.authorTekeoğlu, İbrahim
dc.contributor.authorTolu, Sena
dc.contributor.authorToprak, Murat
dc.contributor.authorTuncer, Tiraje
dc.date.accessioned2021-04-01T07:11:13Z
dc.date.available2021-04-01T07:11:13Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fizik Tedavi ve Rehabilitasyon Ana Bilim Dalı
dc.description.abstractObjectives: This study aims to compare the clinical characteristics, disease activity, and quality of life (QoL) of patients with psoriatic arthritis (PsA) who use biological and conventional synthetic disease-modifying antirheumatic drugs (DMARDs) in a nationwide cohort throughout Turkey. Patients and methods: A total of 961 patients (346 males, 615 females; mean age: 46.9±12.2 years; range, 18 to 81 years) with PsA according to the classification criteria for PsA were included in the study. The patients’ demographic and clinical characteristics, physical examination results, Disease Activity Score 28, Disease Activity Index for Psoriatic Arthritis and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Psoriasis Area and Severity Index, Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Metrology Index, Hospital Anxiety and Depression Scale, Health Assessment Questionnaire, Psoriatic Arthritis Quality of Life (PsAQoL), and Short Form-36 scores were all recorded. Results: Of the patients, 23% underwent biological DMARD (bDMARD) monotherapy, 42% underwent conventional synthetic DMARD (csDMARD) monotherapy, 10% underwent a csDMARD combination therapy, and 10% underwent a combination bDMARD and csDMARD treatment. The Visual Analog Scale (VAS pain), patient global assessment, physician global assessment, and BASDAI scores were found to be lower among patients using combination treatment of csDMARD and bDMARD, while the swollen joint count was found to be lower among patients using bDMARD. The PsAQoL score was found to be the lowest among patients not using any medication and the highest among those using bDMARD. Conclusion: In our study, patients with PsA were successfully treated with both csDMARD and bDMARD monotherapy. When the biological treatments used for PsA were compared with csDMARD, it was found that biological treatments had a positive effect on both disease activity and the QoL. Combinations of csDMARDs and bDMARDs were preferred in cases in which the disease activity was still high or increased. Because of the highest efficacy of the combined treatment, we highly suggest increasing the number of patients on combined treatment.
dc.identifier.citationKeskin, Y., Nas, K., Kılıç, E., Sargın, B., Acer Kasman, S., Alkan, H. ... Tuncer, T. (2021). Clinical characteristics, disease activity, functional status, and quality of life results of patients with psoriatic arthritis using biological and conventional synthetic disease-modifying antirheumatic drugs. Archives of Rheumatology, 36(1), 1-9. https://dx.doi.org/10.46497/ArchRheumatol.2021.7874
dc.identifier.doi10.46497/ArchRheumatol.2021.7874
dc.identifier.endpage9
dc.identifier.issn2148-5046
dc.identifier.issn1309-0283
dc.identifier.issue1
dc.identifier.scopusqualityQ4
dc.identifier.startpage1
dc.identifier.urihttps://dx.doi.org/10.46497/ArchRheumatol.2021.7874
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6667
dc.identifier.volume36
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish League Against Rheumatism
dc.relation.ispartofArchives of Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectDisease-Modifying Antirheumatic Drug
dc.subjectFunctional Status
dc.subjectPsoriatic Arthritis
dc.subjectQuality of Life
dc.titleClinical characteristics, disease activity, functional status, and quality of life results of patients with psoriatic arthritis using biological and conventional synthetic disease-modifying antirheumatic drugs
dc.typeArticle

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