Therapeutic role of rifampicin in Alzheimer's disease
| dc.authorid | 0000-0002-9704-6173 | |
| dc.authorid | 0000-0003-4292-5717 | |
| dc.authorid | 0000-0002-1079-8832 | |
| dc.authorid | 0000-0001-6494-8923 | |
| dc.contributor.author | Yuluğ, Burak | |
| dc.contributor.author | Hano?lu, Lütfü | |
| dc.contributor.author | Ozansoy, Mehmet | |
| dc.contributor.author | Işık, Doğan | |
| dc.contributor.author | Kılıç, Ülkan | |
| dc.contributor.author | Kılıç, Ertuğrul | |
| dc.contributor.author | Schabitz, Wolf Rüdiger | |
| dc.date.accessioned | 10.07.201910:49:13 | |
| dc.date.accessioned | 2019-07-10T19:50:52Z | |
| dc.date.available | 10.07.201910:49:13 | |
| dc.date.available | 2019-07-10T19:50:52Z | |
| dc.date.issued | 2018 | |
| dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı | |
| dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | |
| dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı | |
| dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı | |
| dc.description | WOS: 000426795500003 | |
| dc.description | PubMed ID: 29315976 | |
| dc.description.abstract | Rifampicin exerts significant brain protective functions in multiple experimental models. Here we summarize the underlying mechanisms of the neuroprotective and pro-cognitive effects of rifampicin that are mediated by its anti-inflammatory, anti-tau, anti-amyloid, and cholinergic effects. Beyond suggesting that rifampicin shows strong brain protective effects in preclinical models of Alzheimer's disease, we also provide substantial clinical evidence for the neuroprotective and procognitive effects of rifampicin. Future neuroimaging studies combined with clinical assessment scores are the following steps to be taken in this field of research. | |
| dc.identifier.citation | Yuluğ, B., Hano?lu, L., Ozansoy, M., Işık, D., Kılıç, Ü., Kılıç, E. ... Schabitz, W. (2018). Therapeutic role of rifampicin in Alzheimer's disease. Psychiatry and Clinical Neurosciences, 72(3), 152-159. https://dx.doi.org/10.1111/pcn.12637 | |
| dc.identifier.doi | 10.1111/pcn.12637 | |
| dc.identifier.endpage | 159 | |
| dc.identifier.issn | 1323-1316 | |
| dc.identifier.issn | 1440-1819 | |
| dc.identifier.issue | 3 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.startpage | 152 | |
| dc.identifier.uri | https://dx.doi.org/10.1111/pcn.12637 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/2094 | |
| dc.identifier.volume | 72 | |
| dc.identifier.wosquality | Q1 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Wiley | |
| dc.relation.ispartof | Psychiatry and Clinical Neurosciences | en_US |
| dc.relation.publicationcategory | Diğer | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Alzheimer's Disease | |
| dc.subject | Amyloid Beta Clearance | |
| dc.subject | Neuroprotection | |
| dc.subject | Oligomeric Amyloid Hypothesis | |
| dc.subject | Rifampicin | |
| dc.title | Therapeutic role of rifampicin in Alzheimer's disease | |
| dc.type | Review Article |
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