Neopapillarine, an unusual coumarino-alkaloid from the root extract of neocryptodiscus papillaris with cytotoxic activity on renal cancer cells
| dc.authorid | 0000-0003-2533-5141 | |
| dc.contributor.author | Tosun, Fatma | |
| dc.contributor.author | Mihoğlugil, Feyyaz | |
| dc.contributor.author | Beutler, John A. A. | |
| dc.contributor.author | Eroğlu Özkan, Esra | |
| dc.contributor.author | Miski, Mahmut | |
| dc.date.accessioned | 2020-09-03T06:54:51Z | |
| dc.date.available | 2020-09-03T06:54:51Z | |
| dc.date.issued | 2020 | |
| dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı | |
| dc.description.abstract | Several simple and prenylated coumarin derivatives were isolated from the dichloromethane extract of the root of Neocryptodiscus papillaris based on moderate cytotoxic activity of the extract in COLO205, KM12 and MCF7 cancer cells. While the major prenylated furanocoumarin derivatives and osthol isolated from the dichloromethane extract were responsible for the activity in the colon and breast cancer cell lines, the 4'-acylated osthol derivatives including a novel coumarino-alkaloid; neopapillarine) demonstrated selective cytotoxic activity in A498 and UO31 renal cancer cell lines. | |
| dc.description.sponsorship | Gazi University United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Cancer Institute (NCI) | en_US |
| dc.identifier.citation | Tosun, F., Mihoğlugil, F., Beutler, J. A. A., Eroğlu Özkan, E. ve Miski, M. (2020). Neopapillarine, an unusual coumarino-alkaloid from the root extract of neocryptodiscus papillaris with cytotoxic activity on renal cancer cells. Molecules, 25(13). https://dx.doi.org/10.3390/molecules25133040 | |
| dc.identifier.doi | 10.3390/molecules25133040 | |
| dc.identifier.issn | 1420-3049 | |
| dc.identifier.issue | 13 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.uri | https://dx.doi.org/10.3390/molecules25133040 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/5765 | |
| dc.identifier.volume | 25 | |
| dc.identifier.wosquality | Q2 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | MDPI | |
| dc.relation.ispartof | Molecules | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | Attribution 4.0 International | * |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject | Neocryptodiscus Papillaris | |
| dc.subject | Apiaceae | |
| dc.subject | Simple Coumarins | |
| dc.subject | Furanocoumarins | |
| dc.subject | Prenylated Coumarins | |
| dc.subject | Coumarino-Alkaloid | |
| dc.subject | Cytotoxic Activity | |
| dc.title | Neopapillarine, an unusual coumarino-alkaloid from the root extract of neocryptodiscus papillaris with cytotoxic activity on renal cancer cells | |
| dc.type | Article |
