Impact on genitourinary function and quality of life following focal irreversible electroporation of different prostate segments

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dc.authorid0000-0002-6308-1763
dc.contributor.authorScheltema, Matthijs J.
dc.contributor.authorChang, John I.
dc.contributor.authorvan den Bos, Willemien
dc.contributor.authorGielchinsky, Ilan
dc.contributor.authorNguyen, Tuan V.
dc.contributor.authorde Reijke, Theo M.
dc.contributor.authorSiriwardana, Amila R.
dc.contributor.authorBohm, Maret
dc.contributor.authorde la Rosette, Jean J. M. C. H.
dc.contributor.authorStricker, Phillip D.
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:51Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:51Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.descriptionAnnual Meeting of the Western-Section of the American-Urological-Association (AUA) -- AUG 06-10, 2017 -- Vancouver, CANADA
dc.descriptionWOS: 000444189400004
dc.descriptionPubMed ID: 30211680
dc.description.abstractPURPOSE We aimed to evaluate the genitourinary function and quality of life (QoL) following the ablation of different prostate segments with irreversible electroporation (IRE) for localized prostate cancer (PCa). METHODS Sixty patients who received primary focal IRE for organ-confined PCa were recruited for this study. Patients were evaluated for genitourinary function and QoL per prostate segment treated (anterior vs. posterior, apex vs. base vs. apex-to-base, unilateral vs. bilateral). IRE system settings and patient characteristics were compared between patients with preserved vs. those with impaired erectile function and urinary continence. Data were prospectively collected at baseline, 3, 6, and 12 months using the expanded prostate cancer index composite, American Urological Association symptom score, SF-12 physical and mental component summary surveys. Difference over time within segments per questionnaire was evaluated using the Wilcoxon's signed rank test. Outcome differences between segments were assessed using covariance models. Baseline measurements included questionnaire scores, age, and prostate volume. RESULTS There were no statistically significant changes over time for overall urinary (P = 0.07-0.89), bowel (P = 0.06-0.79), physical (P = 0.18-0.71) and mental (P = 0.45-0.94) QoL scores within each segment. Deterioration of sexual function scores was observed at 6 months within each segment (P = 0.001-0.16). There were no statistically significant differences in QoL scores between prostate segments (P = 0.08-0.97). Older patients or those with poor baseline sexual function at time of treatment were associated with a greater risk of developing erectile dysfunction. CONCLUSION IRE is a feasible modality for all prostate segments without any significantly different effect on the QoL outcomes. Older patients and those with poor sexual function need to be counseled regarding the risk of erectile dysfunction.
dc.description.sponsorshipAmerican Urological Association, Western Secten_US
dc.description.sponsorshipAustralian Prostate Cancer Research Centre-NSW; St. Vincent's Prostate Cancer Centreen_US
dc.description.sponsorshipThe Australian Prostate Cancer Research Centre-NSW and the St. Vincent's Prostate Cancer Centre funded this research project.en_US
dc.identifier.citationScheltema, M., Chang, J., Van den Bos, W., Gielchinsky, I., Nguyen, T., de Reijke, T. ... Stricker, P. (2018). Impact on genitourinary function and quality of life following focal irreversible electroporation of different prostate segments. Diagnostic and Interventional Radiology, 24(5), 268-275. https://dx.doi.org/10.5152/dir.2018.17374
dc.identifier.doi10.5152/dir.2018.17374
dc.identifier.endpage275
dc.identifier.issn1305-3612
dc.identifier.issue5
dc.identifier.scopusqualityQ2
dc.identifier.startpage268
dc.identifier.urihttps://dx.doi.org/10.5152/dir.2018.17374
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2295
dc.identifier.volume24
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAVES
dc.relation.ispartofDiagnostic and Interventional Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleImpact on genitourinary function and quality of life following focal irreversible electroporation of different prostate segments
dc.typeArticle

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