A new type of Anatolian propolis: Evaluation of its chemical composition, activity profile and botanical origin

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dc.contributor.authorDeğirmencioğlu, Hacer Tuğba
dc.contributor.authorGüzelmeriç, Etil
dc.contributor.authorYüksel, Parla Işıl
dc.contributor.authorKırmızıbekmez, Hasan
dc.contributor.authorDeniz, İnci
dc.contributor.authorYeşilada, Erdem
dc.date.accessioned2019-12-19T09:21:27Z
dc.date.available2019-12-19T09:21:27Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı
dc.description.abstractThis study was undertaken to analyze the phenolic profiles of 19 propolis samples from Turkey by using a high-performance thin-layer chromatographic (HPTLC) method in order to identify their plant origins. Furthermore, their antioxidant and antimicrobial activity profiles were comparatively evaluated. For the appraisal of antioxidant potential, total phenolic (TPC) and total flavonoid contents (TFC) of propolis samples were firstly determined and then their effects on free radicals were evaluated by FRAP, ABTS(.+), CUPRAC, DPPH. and HPTLC-DPPH. methods. Antimicrobial activity of propolis samples against Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 15442), Escherichia coli (ATCC 11229) and Candida albicans ATCC 10231 were determined by disc diffusion and broth dilution methods. HPTLC fingerprinting analyses revealed that O-type (botanical origin from Populus nigra L.) was the primarily available propolis type in Turkey. Moreover, 3-O-methylquercetin (3MQ) rich propolis was identified as a new propolis type for the first time. Principal component analysis (PCA) indicated that 3MQ-type propolis differs from the O-type. Antioxidant activity studies showed that O-type of propolis possesses higher antioxidant effect than the other tested propolis types. Quercetin, caffeic acid, caffeic acid phenethyl ester (CAPE) and galangin were determined to contribute significantly to the antioxidant potential of O-type propolis among others. Propolis extracts exerted moderate antimicrobial activity against the tested microorganisms with MIC values between the ranges of 128-512 mu g/mL.
dc.identifier.citationDeğirmencioğlu, H. T., Güzelmeriç, E., Yüksel, P. I., Kırmızıbekmez, H., Deniz, İ. ve Yeşilada, E. (2019). A new type of Anatolian propolis: Evaluation of its chemical composition, activity profile and botanical origin. Chemistry & Biodiversity, 16(12). https://doi.org/10.1002/cbdv.201900492
dc.identifier.doi10.1002/cbdv.201900492
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue12
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/cbdv.201900492
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4542
dc.identifier.volume16
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofChemistry & Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectPropolis
dc.subjectHigh-Performance Thin-Layer Chromatography (HPTLC)
dc.subjectAntimicrobial Activity
dc.subjectPrincipal Component Analysis
dc.titleA new type of Anatolian propolis: Evaluation of its chemical composition, activity profile and botanical origin
dc.typeArticle

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