Should botulinum toxin a injections be repeated in children with cerebral palsy? A systematic review

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dc.contributor.authorKahraman, Aysu
dc.contributor.authorSeyhan, Kübra
dc.contributor.authorDeğer, Ünal
dc.contributor.authorKutlutürk, Seval
dc.contributor.authorMutlu, Akmer
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:49Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:49Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Fizyoterapi ve Rehabilitasyon Bölümü
dc.descriptionWOS: 000382852000011
dc.descriptionPubMed ID: 27103334
dc.description.abstractAimThe aim of this study was to determine the effects of repeat botulinum toxin A (BoNT-A) injections in children with spastic cerebral palsy (CP) on the basis of a best evidence synthesis. MethodThis study included 13 original articles after searching the literature to retrieve information. We used the critical review form produced by McMaster University to determine the methodological quality of the studies, and then confirmed the levels of evidence from Sackett. The studies were also evaluated using the International Classification of Function, Disability and Health - Children and Youth Version (ICF-CY). ResultsA total of 893 children with spastic CP who had been administered repeat BoNT-A injections were evaluated. The evidence level was II in four of the thirteen studies, III in four studies, and IV in five studies. The McMaster review form score was 14 in two studies, 13 in four studies, and 12 in seven studies. The results showed that repeat BoNT-A may be a safe and an effective approach. The first two injections/one repeat especially relieve spasticity and improve fine and gross motor activities. InterpretationFuture studies to investigate the effectiveness of repeat BoNT-A in children with spastic CP may be planned within the framework of the ICF-CY to include well-designed randomized controlled trials and those conducted on larger homogenous groups.
dc.identifier.citationKahraman, A., Seyhan, K., Değer, Ü., Kutlutürk, S. ve Mutlu, A. (2016). Should botulinum toxin a injections be repeated in children with cerebral palsy? A systematic review. Developmental Medicine And Child Neurology, 58(9), 910-917. https://dx.doi.org/10.1111/dmcn.13135
dc.identifier.doi10.1111/dmcn.13135
dc.identifier.endpage917
dc.identifier.issn0012-1622
dc.identifier.issn1469-8749
dc.identifier.issue9
dc.identifier.scopusqualityQ1
dc.identifier.startpage910
dc.identifier.urihttps://dx.doi.org/10.1111/dmcn.13135
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2290
dc.identifier.volume58
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofDevelopmental Medicine And Child Neurologyen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBotulinum Toxin
dc.subjectChildren With Cerebral Palsy
dc.subjectRepeated
dc.titleShould botulinum toxin a injections be repeated in children with cerebral palsy? A systematic review
dc.typeReview Article

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