Investigation of antioxidant and anticonvulsant activity of Hypericum triquetrifolium Turra

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dc.authorid0000-0001-8294-0802
dc.authorid0000-0002-2018-9619
dc.contributor.authorKırmızı Sönmez, Neriman İpek
dc.contributor.authorGüler, Ece
dc.contributor.authorÇam, Muhammet Emin
dc.contributor.authorErmanoğlu, Mizgin
dc.contributor.authorGürdal, Bahar
dc.contributor.authorTaşkın, Turgut
dc.contributor.authorOmurtag, Gülden Zehra
dc.date.accessioned2022-12-05T09:20:09Z
dc.date.available2022-12-05T09:20:09Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Toksikoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractEpilepsy is a state characterized by sudden, recurrent epileptic seizures that are not initiated by an identifiable event. There are various studies has been shown that Hypericum species may be used for their anticonvulsant potentials. Besides, the relationship between anticonvulsant activity and antioxidant effect has already been shown in the literature. In the current study, H. triquetrifolium was investigated for the first time for its potential antioxidant and anticonvulsant potential using in vitro and in vivo test models. H. triquetrifolium extracts were tested with DPPH assay, FRAP assay, copper (II) ion reducing antioxidant capacity assay, and acetylcholinesterase inhibitory activity assay to understand their antioxidant potential. Especially, methanolic extract of H. triquetrifolium was shown the highest antioxidant activity. Moreover, a pentylenetetrazole (PTZ, 80 mg/kg, i.p.)-induced seizure model was conducted to analyze the anticonvulsant activities of H. triquetrifolium extracts in mice. In addition, this study revealed that H. triquetrifolium decreased the ratio of severe seizures and increased the mean onsite of mortality and survival rate in a dose-dependent manner. It is thought that the anticonvulsant effect may be either related to the antioxidant potential of H. triquetrifolium or its interference in the GABAergic system.
dc.identifier.citationKırmızı Sönmez, N. İ., Güler, E., Çam, M. E., Ermanoğlu, M., Gürdal, B., Taşkın, T. ... Omurtag, G. Z. (2022). Investigation of antioxidant and anticonvulsant activity of Hypericum triquetrifolium Turra. Journal of Research in Pharmacy, 26(6), 1877-1883. https://doi.org/10.29228/jrp.277
dc.identifier.doi10.29228/jrp.277
dc.identifier.endpage1883
dc.identifier.issn2630-6344
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85142192458
dc.identifier.scopusqualityQ3
dc.identifier.startpage1877
dc.identifier.urihttps://doi.org/10.29228/jrp.277
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10073
dc.identifier.volume26
dc.identifier.wos000893010600034en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorKırmızı Sönmez, Neriman İpek
dc.institutionauthorOmurtag, Gülden Zehra
dc.language.isoen
dc.publisherMarmara University
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHypericum Triquetrifolium Turra
dc.subjectAntioxidant Activity
dc.subjectAnticonvulsant Activity
dc.subjectEpilepsy
dc.subjectHypericaceae
dc.titleInvestigation of antioxidant and anticonvulsant activity of Hypericum triquetrifolium Turra
dc.typeArticle

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