The effect of vitamin D status on different neuromuscular blocker agents reverse time

Yorulmaz, İlknur Suidiye; Demiraran, Yavuz; Özlü, Onur; Dost, Burhan

The effect of vitamin D status on different neuromuscular blocker agents reverse time

dc.authorid	0000-0003-0811-4945
dc.contributor.author	Yorulmaz, İlknur Suidiye
dc.contributor.author	Demiraran, Yavuz
dc.contributor.author	Özlü, Onur
dc.contributor.author	Dost, Burhan
dc.date.accessioned	2021-01-27T12:05:53Z
dc.date.available	2021-01-27T12:05:53Z
dc.date.issued	2020
dc.department	İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.description.abstract	Background/aim: This study is aimed to investigate the effects of vitamin D levels on sugammadex and neostigmine reversal times. Material and methods: Eighty patients between the ages of 18 and 65 years, with ASA I-III status who were undergoing surgery under general anesthesia were included in the study. A double blind fashion was used to randomly divide all the patients into two groups. At the end of the operation, sugammadex 2 mg/kg was administered to one group (Group sugammadex) and atropine and neostigmine was administered to the other group (Group neostigmine) intravenously. In the data analysis stage, the group was divided into two subgroups according to sugammadex and group neostigmine in itself, with vitamin D levels above and below 30 ng/mL. Statistical analysis was performed on these 4 groups (Group neostigmine and vitamin D < 30 ng/mL), (Group neostigmine and vitamin D ? 30 ng/mL), (Group sugammadex and vitamin D < 30 ng/mL), (Group sugammadex and vitamin D ? 30 ng/mL). When two responses to train of four (TOF) stimulation were taken, the following times were recorded until extubation phase. The time until TOF value 50%, 70%, 90%, and extubation were recorded. Results: There were statistically significant differences between Group sugammadex and vitamin D < 30 ng/mL and Group sugammadex and vitamin D ? 30 ng/mL (P = 0.007) for extubation times and 50% TOF reach times (P = 0.015). However, there was no difference observed between Group neostigmine and vitamin D < 30 ng/mL and Group neostigmine and vitamin D ? 30 ng/mL (P = 0.999). Conclusion: Vitamin D deficiency is important for anesthesiologists in terms of muscle strength and extubation time. Vitamin D deficiency seems to affect sugammadex reverse times but seems not to affect neostigmine reverse times. This conclusion needs further studies.
dc.description.sponsorship	Düzce Üniversitesi	en_US
dc.identifier.citation	Yorulmaz, İ. S., Demiraran, Y., Özlü, O. ve Dost, B. (2020). The effect of vitamin D status on different neuromuscular blocker agents reverse time. Turkish Journal of Medical Sciences, 50(4), 749-755. https://dx.doi.org/10.3906/sag-1901-115
dc.identifier.doi	10.3906/sag-1901-115
dc.identifier.endpage	755
dc.identifier.issn	1300-0144
dc.identifier.issn	1303-6165
dc.identifier.issue	4
dc.identifier.scopusquality	Q3
dc.identifier.startpage	749
dc.identifier.uri	https://dx.doi.org/10.3906/sag-1901-115
dc.identifier.uri	https://hdl.handle.net/20.500.12511/6419
dc.identifier.volume	50
dc.identifier.wosquality	Q4
dc.indekslendigikaynak	Web of Science
dc.indekslendigikaynak	Scopus
dc.indekslendigikaynak	TR-Dizin
dc.indekslendigikaynak	PubMed
dc.language.iso	en
dc.publisher	Türkiye Klinikleri
dc.relation.ispartof	Turkish Journal of Medical Sciences	en_US
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rights	Attribution 4.0 International	*
dc.rights	info:eu-repo/semantics/openAccess
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject	Anaesthesia
dc.subject	Neostigmine
dc.subject	Sugammadex
dc.subject	Vitamin D
dc.subject	Muscle Relaxation
dc.subject	Neuromuscular Blocker
dc.title	The effect of vitamin D status on different neuromuscular blocker agents reverse time
dc.type	Article