Glyconanoparticles for targeted tumor therapy of platinum anticancer drug

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dc.authorid0000-0003-2493-9664
dc.contributor.authorDağ, Aydan
dc.contributor.authorOmurtag Özgen, Pınar Sinem
dc.contributor.authorAtasoy, Sezen
dc.date.accessioned2019-12-19T07:16:22Z
dc.date.available2019-12-19T07:16:22Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalı
dc.description.abstractAn important requirement to decrease the side effects of chemotherapy drugs is to develop nanocarriers with precise biological functions. In this work, a set of glyconanoparticles was prepared via self-assembly of amphiphilic glycoblock copolymers for the targeted delivery of a hydrophobic chemotherapy drug. Well-defined glycoblock copolymers that consist of 1,1-di-tert-butyl 3-(2-(metyloyloxy)ethyl)-butane-1,1,3-tricarboxylate (MAETC) together with three different protected-sugar moieties (?-d-glucopyranoside, ?-d-mannopyranoside, and ?-l-fucopyranoside) were synthesized by using reversible addition-fragmentation chain-transfer polymerization. Copolymers were deprotected and conjugated with the cis-dichlorodiammineplatinum(II) (cis-Pt) anticancer drug. Dynamic light scattering and transmission electron microscopy measurements revealed that cis-Pt-conjugated glyconanoparticles were sufficiently stable under physiological conditions and had diameters of approximately 100 nm with considerably narrow size distributions. They were intracellularly taken up by the breast cancer (MCF-7 and MDA-MB-231), prostate cancer (PC3), renal cancer (769-P), and Chinese hamster ovary cell lines. The PC3 and 769-P cell lines showed a high preference for the glycosylated nanoparticles. Glycoblock copolymers were found nontoxic but showed high cytotoxicity and increased efficacy after conjugation with the cis-Pt anticancer drug. Moreover, in vitro cytotoxicity assays in cancer cell lines demonstrate that cis-Pt-loaded glycopolymer-based nanoparticles have higher cytotoxicity than free cis-Pt. Overall, our results suggest that glyconanoparticles have a great potential to be used as an effective cis-Pt drug carrier for targeted cancer therapy.
dc.identifier.citationDağ, A., Omurtag Özgen, P. S. ve Atasoy, S. (2019). Glyconanoparticles for targeted tumor therapy of platinum anticancer drug. Biomacromolecules, 20(8), 2962-2972. http://dx.doi.org/10.1080/19186444.2019.1616508
dc.identifier.doi10.1021/acs.biomac.9b00528
dc.identifier.endpage2972
dc.identifier.issn1525-7797
dc.identifier.issn1526-4602
dc.identifier.issue8
dc.identifier.scopusqualityQ1
dc.identifier.startpage2962
dc.identifier.urihttp://dx.doi.org/10.1080/19186444.2019.1616508
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4533
dc.identifier.volume20
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relation.ispartofBiomacromoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCross-Linked Micelles
dc.subjectGlucose Transporters
dc.subjectPolymerıc Micelles
dc.subjectGlucose-Transporter-1 Glut-1
dc.subjectGold Nanoparticles
dc.subjectCell-Line
dc.subjectExpression
dc.subjectDelivery
dc.subjectCisplatin
dc.subjectProliferation
dc.titleGlyconanoparticles for targeted tumor therapy of platinum anticancer drug
dc.typeArticle

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