Histopathology of giant cell tumors of the bone: With special emphasis on fibrohistiocytic and aneurysmal bone cyst like components

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dc.contributor.authorÇomunoğlu, Nil
dc.contributor.authorKepil, Nuray
dc.contributor.authorDervişoğlu, Sergülen
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:47Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:47Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.descriptionWOS: 000464719700007
dc.descriptionPubMed ID: 30392920
dc.description.abstractObjective: The aim of this study was to define histopathological features of giant cell tumor of bone, especially accompanying fibrohistiocytic or aneurysmal bone cyst like components, in the light of our institutions experience. Methods: A total of 120 cases (64 females and 56 males; mean age: 36.2 (12-80)) with 'GCT' diagnosed between the years 1996-2016 were included in this retrospective analysis. Cases were evaluated according to clinical features such as age, gender, localization, recurrence, metastasis and histopathological features. Results: Tumors were localized most frequently at proximal tibia and distal femur, respectively. In 11 cases areas rich in fibrohistiocytic component and in 20 cases aneurysmal bone cyst like component were observed. In 2 cases both components were present. Twenty three cases recurred. In 1 case which was primarily located at calcaneus, tumor metastasized to lung 4 years later during follow-up. Conclusion: GCT can be confused with other tumor or tumor-like lesions involving giant cells. Secondary changes such as fibrohistiocytic or aneurysmal bone cyst-like components and coagulation necrosis were frequently seen in conventional giant cell tumor of bone. For tumors having prominent fibrohistiocytic and/or aneurysmal bone cyst-like components, in order to detect characteristic areas representing GCT, additional sampling is essential. Although secondary histopathological changes do not appear to affect clinical outcome, these features are important in differential diagnosis. Approximately one fifth of GCT cases show recurrence and sacrum and foot bones were the most frequent sites for recurrence.
dc.identifier.citationÇomunoğlu, N., Kepil, N. ve Dervişoğlu, S. (2019). Histopathology of giant cell tumors of the bone: With special emphasis on fibrohistiocytic and aneurysmal bone cyst like components. Acta Orthopaedica et Traumatologica Turcica, 53(1), 35-39. https://dx.doi.org/10.1016/j.aott.2018.10.007
dc.identifier.doi10.1016/j.aott.2018.10.007
dc.identifier.endpage39
dc.identifier.issn1017-995X
dc.identifier.issue1
dc.identifier.scopusqualityQ2
dc.identifier.startpage35
dc.identifier.urihttps://dx.doi.org/10.1016/j.aott.2018.10.007
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1765
dc.identifier.volume53
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Assoc Orthopaedics Traumatology
dc.relation.ispartofActa Orthopaedica et Traumatologica Turcicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGiant Cell Tumor of Bone
dc.subjectOsteoclastoma
dc.subjectBone Tumors
dc.subjectPathology
dc.subjectBone
dc.titleHistopathology of giant cell tumors of the bone: With special emphasis on fibrohistiocytic and aneurysmal bone cyst like components
dc.typeArticle

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