Biological activities of the natural coumarins from apiaceae plants

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dc.authorid0000-0003-2533-5141
dc.authorid0000-0003-1896-2729
dc.authorid0000-0002-3412-0807
dc.contributor.authorTosun, Fatma
dc.contributor.authorBiltekin, Sevde Nur
dc.contributor.authorKaradağ, Ayşe Esra
dc.contributor.authorMıhoğlugil, Feyyaz
dc.contributor.authorAkalgan, Demet
dc.contributor.authorMiski, Mahmut
dc.date.accessioned2023-09-29T11:30:45Z
dc.date.available2023-09-29T11:30:45Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractNineteen natural coumarins; badrakemin (1), colladonin (2), 14'-acetoxybadrakemin (3), anatolicin (4), 14'-hydroxycolladonin (5), badrakemone (6), karatavicinol (7), 14'-acetoxybadrakemone (8), 14'-acetoxycolladonin (9), colladonin acetate (10), deltoin (11), smyrnioridin (12), isoimperatorin (13), oxypeucedanin (14), bergapten (15), osthol (16), 4'-senecioyloxyostol (17), neopapillarine (18), and scoparone (19) were tested against U87MG, A549, and PC3 cancer cell lines as well as against healthy human embryonic kidney cell line, HEK293. Colladonin (2) was found to have IC50 values of 12.6 and 11.58 µM in A549 and PC3 cell lines, respectively. Deltoin (11) and 14'-acetoxybadrakemin (3) were found to have an IC50 value of 9.92 µM and 11.85 µM against the U87MG cell line, respectively. Remarkably, these compounds show very low cytotoxicity against the healthy human embryonic kidney cell line, HEK293. In addition to the cytotoxic activity, nineteen natural coumarins were tested for their inhibitory activity against 5-LOX, collagenase, and elastase enzymes.
dc.identifier.citationTosun, F., Biltekin, S. N., Karadağ, A. E., Mıhoğlugil, F., Akalgan, D. ve Miski, M. (2023). Biological activities of the natural coumarins from apiaceae plants. Records of Natural Products, 17(5), 867-877. https://doi.org/10.6135/rnp.396.2304.2758
dc.identifier.doi10.6135/rnp.396.2304.2758
dc.identifier.endpage877
dc.identifier.issn1307-6167
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85171361349
dc.identifier.scopusqualityQ3
dc.identifier.startpage867
dc.identifier.urihttps://doi.org/10.6135/rnp.396.2304.2758
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11506
dc.identifier.volume17
dc.identifier.wos001015042100001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTosun, Fatma
dc.institutionauthorBiltekin, Sevde Nur
dc.institutionauthorKaradağ, Ayşe Esra
dc.language.isoen
dc.publisherACG Publications
dc.relation.ispartofRecords of Natural Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCollagenase
dc.subjectCoumarin
dc.subjectCytotoxicity
dc.subjectElastase
dc.subjectLipoxygenase
dc.titleBiological activities of the natural coumarins from apiaceae plants
dc.typeArticle

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