Treatment of prediabetes

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dc.contributor.authorKanat, Mustafa
dc.contributor.authorDeFronzo, Ralph
dc.contributor.authorAbdul-Ghani, Muhammad
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:04:37Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:04:37Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000362084500001
dc.descriptionPubMed ID: 26464759
dc.description.abstractProgression of normal glucose tolerance (NGT) to overt diabetes is mediated by a transition state called impaired glucose tolerance (IGT). Beta cell dysfunction and insulin resistance are the main defects in type 2 diabetes mellitus (type 2 DM) and even normoglycemic IGT patients manifest these defects. Beta cell dysfunction and insulin resistance also contribute to the progression of IGT to type 2 DM. Improving insulin sensitivity and/or preserving functions of beta-cells can be a rational way to normalize the GT and to control transition of IGT to type 2 DM. Loosing weight, for example, improves whole body insulin sensitivity and preserves beta-cell function and its inhibitory effect on progression of IGT to type 2 DM had been proven. But interventions aiming weight loss usually not applicable in real life. Pharmacotherapy is another option to gain better insulin sensitivity and to maintain beta-cell function. In this review, two potential treatment options (lifestyle modification and pharmacologic agents) that limits the IGT-type 2 DM conversion in prediabetic subjects are discussed.
dc.identifier.citationKanat, M., DeFronzo, R. ve Abdul-Ghani, M. (2015). Treatment of prediabetes. World Journal of Diabetes, 6(12), 1207-1222. https://dx.doi.org/10.4239/wjd.v6.i12.1207
dc.identifier.doi10.4239/wjd.v6.i12.1207
dc.identifier.endpage1222
dc.identifier.issn1948-9358
dc.identifier.issue12
dc.identifier.startpage1207
dc.identifier.urihttps://dx.doi.org/10.4239/wjd.v6.i12.1207
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4082
dc.identifier.volume6
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBaishideng Publishing Group
dc.relation.ispartofWorld Journal of Diabetesen_US
dc.relation.publicationcategoryDiğer
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectPrediabetes
dc.subjectImpaired Fasting Glucose
dc.subjectImpared Glucose Tolerance
dc.subjectDiabetes Prevention
dc.subjectType 2 Diabetes Mellitus
dc.titleTreatment of prediabetes
dc.typeReview Article

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