The effects of some imidazopyrazine derivatives on telomerase inhibition, mtDNA damage and mtDNA copy number

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dc.authorid0000-0002-0841-1299
dc.contributor.authorMutlu, Ayşe Gül
dc.contributor.authorBilginer, Abdulkerim
dc.contributor.authorKayağil, İsmail
dc.contributor.authorYıldız, Hülya
dc.contributor.authorBayhan, Ülkü
dc.contributor.authorYılmaz, İnanç
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:14Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:14Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.description.abstractImidazopyrazine derivatives have been studied for their curative effects on some diseases like cancer and neurological problems; also, some of these molecules have been patented. Primary human cells exhibit limited replicative potential but the cancer cells divided unlimitedly with passage in culture. This immortality is mainly a result of telomerase activity. We investigated the possible telomerase inhibitor effect and possible mtDNA damage action of five imidazopyrazine derivatives. Telomerase activities were measured by the PCR-ELISA based TRAP method and mtDNA damage assays were achieved by quantitative PCR. We used zebrafish as a model organism for our research. In the application of 6-(4-Metylphenyl-8-(4-chlorophenyl)imidazo[1,2-a]pyrazine (C19H14N3Cl), it was determined that this compound inhibit telomerase activities to a statistically significant degree. The obtained results from molecular docking studies also supported the experimental results. Accordingly, this compound has the probability to be used as an anti-cancer agent after detailed studies.
dc.description.sponsorshipFirat University Scientific Research Projects Management Unit: 0305-NAP-16, 0214-YL-14en_US
dc.identifier.citationMutlu, A. G., Bilginer, A., Kayağil, İ., Yıldız, H., Bayhan, Ü., Yılmaz, İ. ... Demirayak, Ş. (2017). The effects of some imidazopyrazine derivatives on telomerase inhibition, mtDNA damage and mtDNA copy number. Acta Pharmaceutica Sciencia, 55(3), 31-41. https://dx.doi.org/10.23893/1307-2080.APS.05517
dc.identifier.doi10.23893/1307-2080.APS.05517
dc.identifier.endpage41
dc.identifier.issn1307-2080
dc.identifier.issue3
dc.identifier.scopusqualityQ4
dc.identifier.startpage31
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1101
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.05517
dc.identifier.volume55
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversity of Istanbul
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnticancer Drugs
dc.subjectImidazopyrazine Derivatives
dc.subjectmtDNA Copy Number
dc.subjectmtDNA Damage
dc.subjectTelomerase Inhibition
dc.titleThe effects of some imidazopyrazine derivatives on telomerase inhibition, mtDNA damage and mtDNA copy number
dc.typeArticle

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