Overview of current pharmacotherapeutic options in benign prostatic hyperplasia

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dc.authorid0000-0002-6308-1763
dc.contributor.authorKoudonas, Antonios
dc.contributor.authorAnastasiadis, Anastasios
dc.contributor.authorTsiakaras, Stavros
dc.contributor.authorLangas, Georgios
dc.contributor.authorSavvides, Eliophotos
dc.contributor.authorMykoniatis, Ioannis
dc.contributor.authorMemmos, Dimitrios
dc.contributor.authorBaniotis, Panagiotis
dc.contributor.authorVakalopoulos, Ioannis
dc.contributor.authorde la Rosette, Jean J. M. C. H.
dc.contributor.authorDimitriadis, Georgios
dc.date.accessioned2024-02-14T08:34:14Z
dc.date.available2024-02-14T08:34:14Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractIntroduction: Benign prostatic hyperplasia (BPH) represents the histological entity of prostate cell proliferation, which inflicts a gradually increasing obstruction of the bladder outlet and is accompanied by a progressing manifestation of lower urinary tract symptoms (LUTS). BPH management algorithm includes conservative measures, pharmaceutical agents, and surgical procedures. Areas covered: A comprehensive literature review was performed using PubMed, Scopus, and Google Scholar databases to identify publications written in English, analyzing BPH pharmaceutical treatment. The search was conducted from January 2000 to January 2023. Six main drug classes can be administered, either as monotherapy or in combination. Furthermore, the authors provide current direction of research on future medications, which focuses on a more etiological interference to the BPH pathophysiological mechanism. Expert opinion: The available medications represent an effective first-line step of BPH/LUTS therapy. Currently, the administration of BPH medications is tailored to patient/disease characteristics and entails long-time adherence to therapy. The emergence of new surgical modalities, which combine significantly lower morbidity compared to standard procedures and more durable effects than the available medications, seems to challenge the current treatment algorithm. More direct comparisons and the increasing experience with these surgical modalities will delineate the switch points between various therapy levels along the BPH management sequence.
dc.identifier.citationKoudonas, A., Anastasiadis, A., Tsiakaras, S., Langas, G., Savvides, E., Mykoniatis, I. ... Dimitriadis, G. (2023). Overview of current pharmacotherapeutic options in benign prostatic hyperplasia. Expert Opinion on Pharmacotherapy, 24(14), 1609-1622. https://dx.doi.org/10.1080/14656566.2023.2237406
dc.identifier.doi10.1080/14656566.2023.2237406
dc.identifier.endpage1622
dc.identifier.issn1465-6566
dc.identifier.issn1744-7666
dc.identifier.issue14
dc.identifier.pmid37448198
dc.identifier.scopus2-s2.0-85165464678
dc.identifier.scopusqualityQ2
dc.identifier.startpage1609
dc.identifier.urihttps://dx.doi.org/10.1080/14656566.2023.2237406
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12275
dc.identifier.volume24
dc.identifier.wos001032133600001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorde la Rosette, Jean J. M. C. H.
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofExpert Opinion on Pharmacotherapyen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBenign Prostate Hyperplasia
dc.subjectBladder Outlet Obstruction
dc.subjectDrug Therapy
dc.subjectLower Urinary Tract Symptomatology
dc.subjectPharmacotherapy
dc.subjectPhytotherapy
dc.titleOverview of current pharmacotherapeutic options in benign prostatic hyperplasia
dc.typeReview Article

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