Design, synthesis and biological evaluation of novel tetralone/indanone containing thiosemicarbazone derivatives with selective COX-2 inhibition as anticancer agents

Basit Öğe Kaydı
dc.authorid0000-0003-1896-2729
dc.contributor.authorKuran, Ebru Didem
dc.contributor.authorDincel, Efe Doğukan
dc.contributor.authorBiltekin, Sevde Nur
dc.contributor.authorAkalın-Çiftçi, Gülşen
dc.contributor.authorUlusoy-Güzeldemirci, Nuray
dc.date.accessioned2023-05-09T08:26:25Z
dc.date.available2023-05-09T08:26:25Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractA series of novel tetralone/indanone moiety-bearing thiosemicarbazone derivatives were synthesized and evaluated for their biological activities. The structural elucidations of the compounds were performed by IR spectroscopy, 1H-NMR, 13C-NMR, and elemental analysis. Cytotoxic activity studies against A549 lung adenocarcinoma cells, CCD-19Lu fibroblast cell line were performed. Furthermore, flow cytometric analyses of mitochondrial membrane potential (JC1), caspase 3 activities, cytotoxic activities against HEK 293 immortalized human embriyonic kidney cell lines and MCF7 human breast cancer cell lines, COX-1 and COX-2 enzyme inhibition activities were evaluated for 2e, 2i, 3c, and 3d. In addition to the in vitro analysis, molecular docking studies were employed to explore the possible binding interactions of the title compounds with COX-1 (PDB ID: 3KK6) and COX-2 (PDB ID: 3LN1). Structure-activity relationships, as well as virtual ADME studies, were carried out and a relationship between the biological, electronic, and physicochemical qualifications of the target compounds was determined. Consequently, these derivatives present a leading structure for future drug development due to their straightforward synthesis and relevant bioactivity.
dc.identifier.citationKuran, E. D., Dincel, E. D., Biltekin, S. N., Akalın-Çiftçi, G. ve Ulusoy-Güzeldemirci, N. (2023). Design, synthesis and biological evaluation of novel tetralone/indanone containing thiosemicarbazone derivatives with selective COX-2 inhibition as anticancer agents. Journal of Molecular Structure, 1286. https://doi.org/10.1016/j.molstruc.2023.135626
dc.identifier.doi10.1016/j.molstruc.2023.135626
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85153283242
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2023.135626
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10919
dc.identifier.volume1286
dc.identifier.wos000988037500001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBiltekin, Sevde Nur
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAnticancer Activity
dc.subjectCyclooxygenase
dc.subjectHydrazide-Hydrazones
dc.subjectMolecular Docking
dc.subjectSynthesis
dc.titleDesign, synthesis and biological evaluation of novel tetralone/indanone containing thiosemicarbazone derivatives with selective COX-2 inhibition as anticancer agents
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Biltekin-Sevde Nur-2023.pdf
Boyut:
14.03 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Eczacılık Fakültesi Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu