Cancer-on-chip: a breakthrough organ-on-a-chip technology in cancer cell modeling

Basit Öğe Kaydı
dc.contributor.authorNejati, Babak
dc.contributor.authorShahhosseini, Reza
dc.contributor.authorHajiabbasi, Mobasher
dc.contributor.authorArdabili, Nastaran Safavi
dc.contributor.authorBaktash, Kosar Bagtashi
dc.contributor.authorAlivirdiloo, Vahid
dc.contributor.authorAlipourfard, Iraj
dc.date.accessioned2025-10-06T11:54:09Z
dc.date.available2025-10-06T11:54:09Z
dc.date.issued2025
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi
dc.description.abstractCancer remains one of the leading causes of death worldwide. The unclear molecular mechanisms and complex in vivo microenvironment of tumors make it difficult to clarify the nature of cancer and develop effective treatments. Therefore, the development of new methods to effectively treat cancer is urgently needed and of great importance. Organ-on-a-chip (OoC) systems could be the breakthrough technology sought by the pharmaceutical industry to address ever-increasing research and development costs. The past decade has seen significant advances in the spatial modeling of cancer therapeutics related to OoC technology, improving physiological exposition criteria. This article aims to summarize the latest achievements and research results of cancer cell treatment simulated in a 3D microenvironment using OoC technology. To this end, we will first discuss the OoC system in detail and then demonstrate the latest findings of the cancer cell treatment study by Ooc and how this technique can potentially optimize better modeling of the tumor. The prospects of OoC systems in the treatment of cancer cells and their advantages and limitations are also among the other points discussed in this study.
dc.identifier.citationNejati, B., Shahhosseini, R., Hajiabbasi, M., Ardabili, N. S., Baktash, K. B., Alivirdiloo, V. ... Alipourfard, I. (2025). Cancer-on-chip: a breakthrough organ-on-a-chip technology in cancer cell modeling. Medical and Biological Engineering and Computing, 63(2), 321-337. http://dx.doi.org/10.1007/s11517-024-03199-5
dc.identifier.doi10.1007/s11517-024-03199-5
dc.identifier.endpage337
dc.identifier.issn0140-0118
dc.identifier.issn1741-0444
dc.identifier.issue2
dc.identifier.pmid39400856
dc.identifier.scopus2-s2.0-85206819600
dc.identifier.scopusqualityQ2
dc.identifier.startpage321
dc.identifier.urihttp://dx.doi.org/10.1007/s11517-024-03199-5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13077
dc.identifier.volume63
dc.identifier.wosWOS:001332516300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorShahhosseini, Reza
dc.language.isoen
dc.relation.ispartofMedical and Biological Engineering and Computing
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject2D/3D Culture
dc.subjectBioprinting
dc.subjectCancer Cell Modeling
dc.subjectCancer On-Chip
dc.subjectMicrofluidics
dc.subjectOrgan-On-A-Chip (Ooc)
dc.subjectTumor Microenvironment
dc.titleCancer-on-chip: a breakthrough organ-on-a-chip technology in cancer cell modeling
dc.typeOther

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Shahhosseini-Reza-2025.pdf
Boyut:
1.65 MB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Diğer Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu