Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774

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dc.authorid0000-0003-2143-5268
dc.contributor.authorAyla, Şule
dc.contributor.authorBilir, Ayhan
dc.contributor.authorErtürkoğlu, Şenol
dc.contributor.authorTanrıverdi, Gamze
dc.contributor.authorSoner, Burak Cem
dc.contributor.authorSofuoğlu, Kenan
dc.contributor.authorGhisolfi, Laura
dc.contributor.authorÖktem, Gülperi
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:03:48Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:03:48Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.descriptionWOS: 000431261100036
dc.descriptionPubMed ID: 29714468
dc.description.abstractBackground/aim: In this study, the effects of resveratrol as a natural polyphenol compound, gemcitabine as an antimetabolite that has nucleoside structure analogous to deoxycytidine, and para-aminophenol-derived paracetamol were investigated with single and combined applications in monolayers of the MDAH-2774 human ovarian cancer cell line. Materials and methods: Drugs were evaluated in cell culture with respect to cell proliferation, cell cytotoxicity (trypan blue dye exclusion test), synthesis phase of cell cycle, and cell structure in 24, 48, 72, and 96 h. Result: Resveratrol and gemcitabine diminished both cell proliferation and cell cycle synthesis phase indication in monolayer cell cultures (P < 0.05). All combination groups showed similar effects that were mainly more effective in respect to single usage of resveratrol and gemcitabine in monolayer cell cultures. Conclusion: The effects of gemcitabine, resveratrol, and paracetamol were investigated in monolayers of the MDAH-2774 human ovarian cancer cell line and a decrease in cell number in cell cycle synthesis phase, prevention of cell proliferation, and destruction of cell structure were observed.
dc.identifier.citationAyla, Ş., Bilir, A., Ertürkoğlu, Ş., Tanrıverdi, G., Soner, B. C., Sofuoğlu, K. ... Öktem, G. (2018). Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774. Turkish Journal of Medical Sciences, 48(2), 441-448. https://dx.doi.org/10.3906/sag-1507-193
dc.identifier.doi10.3906/sag-1507-193
dc.identifier.endpage448
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2
dc.identifier.scopusqualityQ3
dc.identifier.startpage441
dc.identifier.urihttps://dx.doi.org/10.3906/sag-1507-193
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3944
dc.identifier.volume48
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOvarian Cancer
dc.subjectGemcitabine
dc.subjectParacetamol
dc.subjectResveratrol
dc.titleEffects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774
dc.typeArticle

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