Emerging roles of extracellular vesicle-associated non-coding RNAs in hypoxia: Insights from cancer, myocardial infarction and ischemic stroke

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dc.authorid0000-0002-1222-9211
dc.contributor.authorHermann, Dirk M.
dc.contributor.authorXin, Wenqiang
dc.contributor.authorBaehr, Mathias
dc.contributor.authorGiebel, Bernd
dc.contributor.authorDoeppner, Thorsten R.
dc.date.accessioned2022-08-05T10:39:57Z
dc.date.available2022-08-05T10:39:57Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.description.abstractHypoxia is a central pathophysiological component in cancer, myocardial infarction and ischemic stroke, which represent the most common medical conditions resulting in long-term disability and death. Recent evidence suggests common signaling pathways in these diverse settings mediated by non-coding RNAs (ncRNAs), which are packaged in extracellular vesicles (EVs) protecting ncRNAs from degradation. EVs are a heterogeneous group of lipid bilayer-covered vesicles released from virtually all cells, which have important roles in intercellular communication. Recent studies pointed out that ncRNAs including long non-coding RNAs (IncRNAs) and microRNAs (miRNAs) are selectively sorted into EVs, modulating specific aspects of cancer development, namely cell proliferation, migration, invasion, angiogenesis, immune tolerance or drug resistance, under conditions of hypoxia in recipient cells. In myocardial infarction and stroke, ncRNAs shuttled via EVs have been shown to control tissue survival and remodeling post-hypoxia by regulating cell injury, inflammatory responses, angiogenesis, neurogenesis or neuronal plasticity. This review discusses recent evidence on EV-associated ncRNAs in hypoxic cancer, myocardial infarction and stroke, discussing their cellular origin, biological function and disease significance. The emerging concept of IncRNA-circular RNA/ miRNA/ mRNA networks is outlined, upon which ncRNAs synergistically respond to hypoxia in order to modify disease responses. Particular notion is given to ncRNAs participating in at least two of the three conditions, which revealed a large degree of overlaps across pathophysiological conditions. Possible roles of EV-ncRNAs as therapeutic products or theranostic markers are defined.
dc.identifier.citationHermann, D. M., Xin, W., Baehr, M., Giebel, B. ve Doeppner, T. R. (2022). Emerging roles of extracellular vesicle-associated non-coding RNAs in hypoxia: Insights from cancer, myocardial infarction and ischemic stroke. Theranostics, 12(12), 5776-5802. https://doi.org/10.7150/thno.73931
dc.identifier.doi10.7150/thno.73931
dc.identifier.endpage5802
dc.identifier.issn1838-7640
dc.identifier.issue12
dc.identifier.pmid35966580
dc.identifier.scopusqualityQ1
dc.identifier.startpage5776
dc.identifier.urihttps://doi.org/10.7150/thno.73931
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9631
dc.identifier.volume12
dc.identifier.wos000829099700019en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDoeppner, Thorsten R.
dc.language.isoen
dc.publisherIvyspring International Publisher
dc.relation.ispartofTheranosticsen_US
dc.relation.publicationcategoryDiÄŸer
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectInhibit Cardiomyocyte Apoptosis
dc.subjectCell Lung-Cancer
dc.subjectCardiac-Function
dc.subjectStromal Cells
dc.subjectIschemia/Reperfusion Injury
dc.subjectPromotes Angiogenesis
dc.titleEmerging roles of extracellular vesicle-associated non-coding RNAs in hypoxia: Insights from cancer, myocardial infarction and ischemic stroke
dc.typeReview Article

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