Evaluation of the in vivo preclinical toxicity of targeted nanoparticles

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dc.authorid0000-0002-2018-9619
dc.contributor.authorCeylan, Cengizhan
dc.contributor.authorTatlıp?nar, Mücteba Eşref
dc.contributor.authorTüccar, Sinem
dc.contributor.authorOmurtag, Gülden Zehra
dc.contributor.authorAkbuğa, Fatma Jülide
dc.date.accessioned2022-04-26T08:18:43Z
dc.date.available2022-04-26T08:18:43Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Toksikoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.description.abstractDrug delivery systems include nanoparticles (NPs), nanoemulsions, nanosuspensions, nanoliposomes, niosomes, dendrimers, fullerene, carbon nanotubes, nanogels, polymeric micelles, and solid lipid NPs. Although the drug-based research of nanotechnology has existed for some time, nanotoxicology (the study of the toxicity of nanomaterials) has only recently been a subject of study in pharmacology. The toxicity of nanocarrier systems covers physicochemical, physiological, and molecular matters. If the NP translocates into the nucleus, direct interaction between NPs and DNA molecules or related proteins may cause physical damage to the genetic material. NPs can affect the fetus in different ways: First, via the direct effect of particle translocation through the placenta and second, the indirect effect of inducing placental dysfunction or activating inflammation or oxidative stress in the mother. Acute toxic class method provides information about risk assessment for short-term exposure to a test chemical through inhalation.
dc.identifier.citationCeylan, C., Tatlıp?nar, M. E., Tüccar, S., Omurtag, G. Z. ve Akbuğa, F. J. (2021). Evaluation of the in vivo preclinical toxicity of targeted nanoparticles. Drug Delivery with Targeted Nanoparticles: In Vitro and in Vivo Evaluation Methods içinde (381-410. ss.). Taylor and Francis. https://doi.org/10.1201/9781003164739-15
dc.identifier.doi10.1201/9781003164739-15
dc.identifier.endpage410
dc.identifier.isbn9781000375268
dc.identifier.isbn9789814877756
dc.identifier.scopus2-s2.0-85128017007
dc.identifier.scopusqualityN/A
dc.identifier.startpage381
dc.identifier.urihttps://doi.org/10.1201/9781003164739-15
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9379
dc.indekslendigikaynakScopus
dc.institutionauthorTatlıp?nar, Mücteba Eşref
dc.institutionauthorTüccar, Sinem
dc.institutionauthorOmurtag, Gülden Zehra
dc.institutionauthorAkbuğa, Fatma Jülide
dc.language.isoen
dc.publisherTaylor and Francis
dc.relation.ispartofDrug Delivery with Targeted Nanoparticles: In Vitro and in Vivo Evaluation Methodsen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNanoparticles
dc.subjectPreclinical Toxicity
dc.subjectDrug
dc.titleEvaluation of the in vivo preclinical toxicity of targeted nanoparticles
dc.typeBook Chapter

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