Microcystic, elongated, and fragmented pattern of invasion in relation to histopathologic and clinical prognostic factors in endometrioid endometrial adenocarcinoma

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dc.authorid0000-0002-6708-7791
dc.contributor.authorNaki, Mehmet Murat
dc.contributor.authorOran, Gülbin
dc.contributor.authorTetikkurt, Seza Ümit
dc.contributor.authorSönmez, Cavide Fatma
dc.contributor.authorTürkmen, İlknur
dc.contributor.authorKöse, Faruk
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:33Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:33Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.descriptionWOS: 000423954800008
dc.descriptionPubMed ID: 28890428
dc.description.abstractObjective: To investigate the association of microcystic, elongated, and fragmented (MELF) pattern of invasion with prognostic factors in endometrioid endometrial adenocarcinoma (EEA). Material and Methods: Stained tissue sections from 83 cases of EEA operated by the same gynecologic oncologist were reviewed to identify cases showing MELF-type invasion in this retrospective study. The association of MELF pattern with age, tumor grade, depth of myometrial invasion, and presence of lymphovascular space invasion (LVSI) was analyzed. Results: FIGO grade 2 and grade 1 tumors were evident in 53.0% and 38.6% of patients, respectively. Depth of myometrial invasion was <50% in 72.0% of patients, and LVSI was absent in 77.1%. MELF pattern was confirmed in 35 (42.2%) patients. Presence of MELF pattern was associated with significantly higher mean +/- standard deviation age (62.9 +/- 6.9) years vs. 58.9 +/- 9.1 years, p=0.033), and found to be more likely in patients with high-grade tumor (FIGO grade III; 85.7% vs. 14.3%, p<0.001), deep (>= 50%) myometrial invasion (78.3% vs. 21.7%, p<0.001), and presence of LVSI (94.7% vs. 5.3%, p<0.001) as compared with absence of MELF pattern. Conclusion: In conclusion, our findings revealed a high rate of MELF pattern among patients with EEA alongside the association of MELF pattern with poor prognostic factors such as high grade tumor, deep myometrial invasion, and LVSI.
dc.identifier.citationNaki, M. N., Oran, G., Tetikkurt, S. Ü., Sönmez, C. F., Türkmen, İ. ve Köse, F. (2017). Microcystic, elongated, and fragmented pattern of invasion in relation to histopathologic and clinical prognostic factors in endometrioid endometrial adenocarcinoma. Journal of the Turkish-German Gynecological Association, 18(3), 139-142. https://dx.doi.org/10.4274/jtgga.2017.0016
dc.identifier.doi10.4274/jtgga.2017.0016
dc.identifier.endpage142
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue3
dc.identifier.scopusqualityQ3
dc.identifier.startpage139
dc.identifier.urihttps://dx.doi.org/10.4274/jtgga.2017.0016
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3334
dc.identifier.volume18
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Yayıncılık
dc.relation.ispartofJournal of the Turkish-German Gynecological Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEndometrioid Endometrial Adenocarcinoma
dc.subjectMicrocystic
dc.subjectElongated
dc.subjectFragmented Pattern
dc.subjectTumor Grade
dc.subjectMyometrial Invasion
dc.subjectLymphovascular Space Invasion
dc.titleMicrocystic, elongated, and fragmented pattern of invasion in relation to histopathologic and clinical prognostic factors in endometrioid endometrial adenocarcinoma
dc.typeArticle

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