SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of kawasaki disease?

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dc.authorid0000-0002-4551-5433
dc.contributor.authorSancho-Shimizu, Vanessa
dc.contributor.authorBrodin, Petter
dc.contributor.authorCobat, Aurelie
dc.contributor.authorBiggs, Catherine M.
dc.contributor.authorToubiana, Julie
dc.contributor.authorLucas, Carrie L.
dc.contributor.authorHenrickson, Sarah E.
dc.contributor.authorBelot, Alexandre
dc.contributor.authorTangye, Stuart G.
dc.contributor.authorMilner, Joshua D.
dc.contributor.authorLevin, Michael
dc.contributor.authorAbel, Laurent
dc.contributor.authorBogunovic, Dusan
dc.contributor.authorCasanova, Jean-Laurent
dc.contributor.authorZhang, Shen-Ying
dc.contributor.authorNepesov, Serdar
dc.date.accessioned2021-10-20T08:17:23Z
dc.date.available2021-10-20T08:17:23Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractMultisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki disease (KD), a well-known but poorly understood and clinically heterogenous pediatric inflammatory condition for which weak associations have been found with a myriad of viral illnesses. Epidemiological data clearly indicate that SARS-CoV-2 is the trigger for MIS-C, which typically occurs about 1 mo after infection. These findings support the hypothesis of viral triggers for the various forms of classic KD. We further suggest that rare inborn errors of immunity (IEIs) altering the immune response to SARS-CoV-2 may underlie the pathogenesis of MIS-C in some children. The discovery of monogenic IEIs underlying MIS-C would shed light on its pathogenesis, paving the way for a new genetic approach to classic KD, revisited as a heterogeneous collection of IEIs to viruses.
dc.description.sponsorshipHoward Hughes Medical Institute ; Rockefeller University ; St. Giles Foundation ; United States Department of Health & Human Services ; National Institutes of Health (NIH) - USA ; National Center for Advancing Translational Sciences, National Institutes of Health Clinical and Translational Science Award program ; Yale Center for Mendelian Genomics ; GSP Coordinating Center - National Human Genome Research Institute ; Institut National de la Sante et de la Recherche Medicale (Inserm) ; Universite de Paris ; French National Research Agency (ANR) ; Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence ; French National Research Agency (ANR) ; Fondation pour la Recherche Medicale ; French National Research Agency (ANR) ; UK Research and Innovation Future Leader's Fellowshipen_US
dc.identifier.citationSancho-Shimizu, V., Brodin, P., Cobat, A., Biggs, C. M., Toubiana, J., Lucas, C. L. ... Nepesov, S. (2021). SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of kawasaki disease? Journal of Experimental Medicine, 218(6). https://dx.doi.org/10.1084/jem.20210446
dc.identifier.doi10.1084/jem.20210446
dc.identifier.issn0022-1007
dc.identifier.issn1540-9538
dc.identifier.issue6
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1084/jem.20210446
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8478
dc.identifier.volume218
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherRockefeller University Press
dc.relation.ispartofJournal of Experimental Medicineen_US
dc.relation.publicationcategoryDiÄŸer
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectCOVID-19
dc.subjectHuman Disease Genetics
dc.subjectImmunodeficiency
dc.subjectInnate Immunity and Inflammation
dc.titleSARS-CoV-2-related MIS-C: A key to the viral and genetic causes of kawasaki disease?
dc.typeReview Article

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