Azelaic acid loaded chitosan and HPMC based hydrogels for treatment of acne: Formulation, characterization, in vitro-ex vivo evaluation

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dc.authorid0000-0001-9290-2404
dc.authorid0000-0003-1035-223X
dc.authorid0000-0002-4121-588X
dc.authorid0000-0001-5605-6159
dc.contributor.authorArpa, Muhammet Davut
dc.contributor.authorSeçen, İkbal Merve
dc.contributor.authorErim, Ümit Can
dc.contributor.authorHoş, Ayşegül
dc.contributor.authorÜstündağ Okur, Neslihan
dc.date.accessioned2022-11-15T12:42:05Z
dc.date.available2022-11-15T12:42:05Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractIn this study, hydrogels containing azelaic acid were developed using chitosan or HPMC (1-7%) for local treatment of acne vulgaris. Physicochemical properties such as viscosity, pH and mechanical properties were evaluated. In vitro release and ex vivo permeability studies were performed using the Franz diffusion cell system. The pH of the hydrogels was highly compatible with the skin pH and varied between 4.38 and 5.84. The cumulative release percentages of the hydrogels at the end of 6 hours were 65-78%, whereas the marketed product yielded 50% drug release. According to the ex vivo permeability results, azelaic acid accumulated in the skin was found to be 9.38 +/- 0.65% (marketed cream), 19.53 +/- 1.06% (K3), 10.96 +/- 1.91% (H6). The antiacne studies with Cutibacterium acnes revealed that K3 (29.45 +/- 0.95) and H6 (32.35 +/- 0.15) had higher inhibition zones compared to the marketed cream (24.50 +/- 0.90). Additionally, the gels were found to be highly stable as a result of the stability studies for 6 months. Among the hydrogels that were prepared based on experimental findings, K3 (3% Chitosan) and H6 (6% HPMC) represented elevated in vitro release profile, higher permeability and increased antiacne activity. The findings of this research suggest that the developed hydrogels might be an alternative to the marketed product.
dc.identifier.citationArpa, M. D., Seçen, İ. M., Erim, Ü. C., Hoş, A. ve Üstündağ Okur, N. (2022). Azelaic acid loaded chitosan and HPMC based hydrogels for treatment of acne: Formulation, characterization, in vitro-ex vivo evaluation. Pharmaceutical Development and Technology, 27(3), 268-281. https://doi.org/10.1080/10837450.2022.2038620
dc.identifier.doi10.1080/10837450.2022.2038620
dc.identifier.endpage281
dc.identifier.isbn1097-9867
dc.identifier.issn1083-7450
dc.identifier.issue3
dc.identifier.pmid35112652
dc.identifier.scopus2-s2.0-85125109507
dc.identifier.scopusqualityQ2
dc.identifier.startpage268
dc.identifier.urihttps://doi.org/10.1080/10837450.2022.2038620
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9966
dc.identifier.volume27
dc.identifier.wos000753842900001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorArpa, Muhammet Davut
dc.institutionauthorSeçen, İkbal Merve
dc.institutionauthorErim, Ümit Can
dc.institutionauthorHoş, Ayşegül
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofPharmaceutical Development and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAcne Vulgaris
dc.subjectAzelaic Acid
dc.subjectHydrogels
dc.subjectChitosan
dc.subjectHPMC
dc.subjectCutibacterium Acnes
dc.subjectPropionibacterium Acnes
dc.titleAzelaic acid loaded chitosan and HPMC based hydrogels for treatment of acne: Formulation, characterization, in vitro-ex vivo evaluation
dc.typeArticle

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